Using high-resolution PET-CT imaging during lung surgery
Perioperative Specimen Imaging Using High-resolution 18F-FDG-PET-CT During Thoracic Surgery: a Pilot Study
This study tests whether using advanced imaging during lung surgery can help doctors see if they've removed all the cancer and make better decisions while operating.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Ghent Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Ghent) |
| Trial ID | NCT05693363 on ClinicalTrials.gov |
What this trial studies
This pilot study investigates the use of a high-resolution PET-CT imaging system during thoracic surgery to evaluate resection margins and lymph node status in real-time. The imaging allows for quick assessments, estimated to take under 10 minutes per specimen, enabling surgeons to make informed decisions on surgical steps as they proceed. The goal is to enhance surgical outcomes by providing immediate feedback on the effectiveness of tumor removal.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with suspected or confirmed lung malignancies who are scheduled for thoracic surgery.
Not a fit: Patients who have contraindications for thoracic surgery, active infections, or high blood glucose levels may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved surgical precision and outcomes for patients undergoing lung cancer surgery.
How similar studies have performed: While this approach is innovative, similar studies using intraoperative imaging have shown promise in improving surgical outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient is 18 years of age or older. * Patient with suspected or confirmed lung malignancies * Patient is indicated to undergo thoracic surgery. * Patient is estimated to be compliant for study participation by the investigator. * Patient has freely given his/her informed consent to participate in this study. Exclusion Criteria: * Patient has general or local contra-indications for thoracic surgery. * Patient has active infection. * Blood glucose level over 200 mg/dL on the day of surgery. * Pregnancy or lactation. * Patient participated in other clinical studies with radiation exposure of more than 1 mSv in the past year
Where this trial is running
Ghent
- University Hospital Ghent — Ghent, Belgium (Recruiting)
Study contacts
- Study coordinator: Liesbeth Desender, prof. dr.
- Email: liesbeth.desender@uzgent.be
- Phone: +32 9 332 63 88
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.