Using high-flow nasal cannula for managing bronchiectasis exacerbations
High Flow Nasal Cannula Versus Non-invasive Ventilation in Managing Acute Exacerbation of Bronchiectasis Patients
Assiut University · NCT05741697
This study is testing if using a high-flow nasal cannula can help people with bronchiectasis who have breathing problems during flare-ups feel better compared to traditional breathing support methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Assiut University (other) |
| Locations | 1 site (Asyut, Asyut Governorate) |
| Trial ID | NCT05741697 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with bronchiectasis who experience exacerbations leading to hypercapnic respiratory failure. It investigates the use of high-flow nasal cannula (HFNC) as a potential alternative to noninvasive ventilation (NIV) for these patients. HFNC delivers heated and humidified gas at high flow rates, which may help reduce the work of breathing and improve gas exchange. The study aims to gather evidence on the effectiveness of HFNC in this specific patient population, as current data is limited.
Who should consider this trial
Good fit: Ideal candidates are adults diagnosed with bronchiectasis who require ventilator support in a respiratory intensive care unit.
Not a fit: Patients under 18 years old, those with post-arrest encephalopathy, previous tracheotomy, invasive ventilatory support, or end-organ failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive and effective treatment option for patients experiencing bronchiectasis exacerbations.
How similar studies have performed: While HFNC has shown benefits in other respiratory conditions, its application in hypercapnic acute respiratory failure remains under-researched, making this study a novel exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients will be eligible for enrolment if diagnosed with bronchiectasis and admitted to the respiratory intensive care unit (RICU), requiring ventilator support without invasive mechanical ventilation. Exclusion Criteria: * Age: less than 18 years. Patients with post-arrest encephalopathy. Patient with the previous tracheotomy. Patients who received invasive ventilatory support. Patients with end-organ failure.
Where this trial is running
Asyut, Asyut Governorate
- Assiut University-Faculty of medicine — Asyut, Asyut Governorate, Egypt (RECRUITING)
Study contacts
- Principal investigator: Ahmad M. Shaddad — Assiut University
- Study coordinator: ahmad shaddad, MD
- Email: shaddad_ahmad@yahoo.com
- Phone: +201111171930
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Bronchiectasis