Using HD-tDCS and Circadian Rhythm Adjustment to Help Patients with Consciousness Disorders
Effect and Mechanism of HD-tDCS Combined With Circadian Rhythm Remodeling on Consciousness Recovery in Patients With Chronic Disorder of Consciousness
NA · First Affiliated Hospital of Zhejiang University · NCT05285124
This study is testing whether a new brain stimulation technique combined with adjusting sleep patterns can help people with consciousness disorders feel more awake and aware.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | First Affiliated Hospital of Zhejiang University (other) |
| Locations | 1 site (Hanzhou, Zhejiang) |
| Trial ID | NCT05285124 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of high-definition transcranial direct current stimulation (HD-tDCS) combined with circadian rhythm reconstruction on patients suffering from chronic disturbances of consciousness. Researchers will monitor patients' sleep cycles and consciousness levels using various methods, including EEG and fMRI, to understand how these interventions may improve consciousness. The study aims to explore the relationship between circadian rhythm disorders and consciousness levels, providing insights into potential treatment mechanisms.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with a disorder of consciousness who have stable vital signs and are not on certain medications.
Not a fit: Patients with locked-in syndrome or those with conditions affecting brain function may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance the recovery of consciousness in patients with chronic disorders.
How similar studies have performed: While the combination of HD-tDCS and circadian rhythm adjustment is innovative, similar studies have shown promise in related areas, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with diagnosis of disorder of consciousness * Stable vital signs * Good coordination, less spontaneous activity * No anti-epileptic and sedative drugs taken within prior 24 hours * The family members volunteered and signed the informed consent Exclusion Criteria: * locked-in syndrome * Diseases and factors that may affect the judgment of brain function, such as metabolic diseases, poisoning, shock, etc. * There are contraindications to MRI scanning, such as the presence of metal implants in the body * Contraindications treated by transcranial direct current stimulation
Where this trial is running
Hanzhou, Zhejiang
- First Affiliated Hospital,Zhejiang University — Hanzhou, Zhejiang, China (RECRUITING)
Study contacts
- Study coordinator: Benyan Luo, PhD
- Email: luobenyan@zju.edu.cn
- Phone: 13967166677
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Disorder of Consciousness, disorder of consciousness, Circadian rhythm, HD-tDCS