Using HCQ before treatment for advanced nasopharyngeal carcinoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of pretreating advanced nasopharyngeal carcinoma (NPC) patients with hydroxychloroquine (HCQ) before they undergo radiotherapy and chemotherapy. The focus is on understanding how HCQ can inhibit the formation of dormant polyploid giant cancer cells (PGCCs), which are linked to cancer recurrence and metastasis. By analyzing the biological properties of PGCCs and their response to treatment, the study aims to improve patient outcomes and reduce the risk of cancer returning after initial therapy. The research utilizes a clinical model to assess the impact of HCQ on PGCC formation and overall survival rates in NPC patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of NPC.
* Have not received any cancer therapies
* Must provide informed consent

Exclusion Criteria:

* With metastasis before the first treatment.

Where it's running

• Bo You
  Nantong, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Bo You, Doctor — Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Nantong University
• Study coordinator: Bo You, Doctor
• Email: youbo19891014@163.com
• Phone: +8615851358688

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.