Using growth factors and allograft to regenerate periodontal tissue
Evaluation of Clinical and Radiographic Parameters in Bony Defects Treated With Recombinant Human Platelet-derived Growth Factor in Combination With Allograft
This study is testing if a special growth factor combined with a tissue graft can help people with gum disease heal better than just using the graft alone.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universidad Autonoma de Nuevo Leon Academic / other |
| Locations | 1 site (Monterrey, Nuevo León) |
| Trial ID | NCT06162832 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of recombinant human platelet-derived growth factor (rH-PDGF-BB) combined with allograft in treating periodontal defects. It involves a comparison between two groups: one receiving the growth factor with allograft and the other receiving allograft with saline solution. Clinical parameters such as probing depth, clinical attachment level, and bleeding index will be assessed at baseline and after six months. The study aims to determine if the growth factor enhances healing and regeneration in patients with periodontitis.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with periodontitis who have specific infrabony defects and are classified as ASA I or II.
Not a fit: Patients undergoing bisphosphonate therapy, those with furcation defects, or pregnant individuals may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve healing outcomes for patients with periodontal diseases.
How similar studies have performed: Previous studies have shown promising results using growth factors in periodontal regeneration, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of periodontitis * Infrabony defects of 2 walls, 3 walls and combined defects * Patients ASA (American Society of Anesthesiologists) I and II * Patients who smoke less than 10 cigarettes Exclusion Criteria: * Patients undergoing bisphosphonate therapy * Furcation defects * Patients with evidence of blood dyscrasias. * Pregnant patient
Where this trial is running
Monterrey, Nuevo León
- Posgrado de Periodoncia, Facultad de Odontología, Universidad Autónoma de Nuevo León — Monterrey, Nuevo León, Mexico (Recruiting)
Study contacts
- Principal investigator: Jessica P Arredondo Muñoz, Resident — Posgrado De Periodoncia, Universidad autónoma de Nuevo León
- Study coordinator: Jesus I Rodriguez Pulido, Dr
- Email: jesus.rodriguezpl@uanl.edu.mx
- Phone: 52 81 83294000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.