Using GPi brain signals to guide DBS programming for primary dystonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site, prospective observational study will enroll adults with primary dystonia who are candidates for GPi DBS and implant the Medtronic Percept device to record chronic local field potentials. The protocol includes an internal pilot and two main cohorts comparing traditional programming based on clinical assessment and imaging with programming guided by LFP peak characteristics. Investigators will examine whether alpha–theta LFP peaks correlate with dystonia severity, how LFP profiles change with stimulation, botulinum toxin, or medications, and whether LFP-guided settings produce similar or better clinical outcomes. Clinical severity measures and continuous LFP recordings from implanted GPi electrodes will be collected over follow-up for comparison.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older at screening.
* Clear clinical diagnosis of primary dystonia (idiopathic or genetic forms).
* Candidate for GPi DBS surgery for dystonia treatment.
* Able to provide informed consent.

Exclusion Criteria:

* Significant neurological or psychiatric disorder (including dementia) that would interfere with outcome evaluation.
* Participation in a therapeutic research trial within the last year.
* Diagnosis of functional (psychogenic) dystonia.

Where it's running

• Clinical Ageing Research Unit,
  Newcastle upon Tyne, Tyne & Wear, United Kingdom Recruiting

Study contacts

• Study coordinator: David Ledingham, MA, MBBS
• Email: david.ledingham1@nhs.net
• Phone: +441912826161

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Measuring brain network activity to predict and improve outcomes in children with dystonia

  This project will test whether noninvasive brain and muscle recordings, and comparing DBS on versus off, can predict and help improve motor outcomes for children with dystonia.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07325175

• Wearable sensors to predict DBS results for people with dystonia

  This study will test whether wearable sensors that record walking patterns before surgery can predict how well deep brain stimulation will work for people with dystonia.

  Recruiting Ruijin Hospital · Shanghai · NCT07323602

• VIM0423 for adults with isolated dystonia affecting multiple body regions

  This trial will test a once-daily oral medicine called VIM0423 to see if it reduces dystonia symptoms and improves daily function in adults with isolated dystonia that affects two or more body regions.

  Recruiting at 37 sites Phase 2 Vima Therapeutics · Birmingham, Alabama and 44 other locations · NCT07304089

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.