Using Gentamicin and Dexamethasone for Bronchiectasis Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the safety and efficacy of local instillation of gentamicin and dexamethasone in patients with bronchiectasis experiencing acute exacerbations while on mechanical ventilation. The study aims to improve mucociliary clearance, reduce bacterial colonization, and alleviate airway inflammation through targeted treatment. Participants will undergo bronchoscopic airway clearance followed by the instillation of the medications to assess their impact on lung function and quality of life. The trial focuses on patients who require antibiotic treatment in a respiratory ICU setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with bronchiectasis confirmed by high-resolution CT chest(HRCT)
* patients with acute exacerbation of bronchiectasis who need antibiotic treatment at the hospital due to exacerbation
* mechanically ventilated patients in the respiratory ICU
* Age more than or equal to 18 years

Exclusion Criteria:

* patients with active pulmonary tuberculosis
* patients with allergic bronchopulmonary aspergillosis
* patients who underwent interventional bronchoscopy for hemoptysis
* age less than 18 years

Where it's running

• Assiut university hospitals
  Asyut, Egypt Recruiting

Study contacts

• Principal investigator: Ali A Ali, MSc — Assiut University
• Study coordinator: Ali A Ali, MSc
• Email: aliabuzaid@aun.edu.eg
• Phone: +2001064756136

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Bronchoscopic Amikacin for Acute Exacerbations in Bronchiectasis

  This study tests whether delivering amikacin directly into the lungs during bronchoscopy helps adults with acute bronchiectasis flare-ups.

  Recruiting First Affiliated Hospital of Ningbo University · Ningbo, Zhejiang · NCT07813299

• Azithromycin added to usual care to see if it lowers bronchiectasis flare-ups

  This trial tests whether taking azithromycin daily for a year reduces bronchiectasis-related flare-ups in adults with non-cystic fibrosis bronchiectasis.

  Recruiting Phase 4 Assiut University · Asyut · NCT07608328

• Bronchiectasis Phenotype Identification Model for Adults

  This study tests a baseline classifier to categorize adults with non-cystic fibrosis bronchiectasis into phenotype groups using data collected over time.

  Recruiting Assiut University · Asyut, Assiut Egypt · NCT07599969

• BASE: Aiming to test a simple, objective way to gauge bronchiectasis severity and predict flare-ups

  This study tests a new BASE framework to classify how severe non-cystic fibrosis bronchiectasis is right now and see if it can predict 12 months of worsening or flare-ups.

  Recruiting Assiut University · Asyut, Asyut Egypt · NCT07599839

• Investigating how cold viruses affect bronchiectasis exacerbations

  This study is trying to see if cold viruses make symptoms worse for people with bronchiectasis compared to healthy individuals.

  Recruiting Imperial College London · London · NCT06931002

• Using acetylcysteine in bronchoalveolar lavage for bronchiectasis treatment

  This study is testing if using acetylcysteine during a lung cleaning procedure can help people with bronchiectasis feel better and recover faster during flare-ups compared to standard treatments.

  Recruiting First Affiliated Hospital of Ningbo University · Ningbo, Zhejiang · NCT06726356

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.