Using acetylcysteine in bronchoalveolar lavage for bronchiectasis treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of bronchoalveolar lavage using acetylcysteine in patients with acute exacerbation of bronchiectasis. A total of 180 patients will be randomly assigned to one of three groups: conventional treatment, bronchoalveolar lavage with saline, or bronchoalveolar lavage with acetylcysteine. The goal is to determine if the addition of acetylcysteine improves patient outcomes compared to standard treatments. The study will assess symptom relief, hospital stay duration, and overall lung function improvements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years and ≤80 years;
2. Chest CT suggestive of bronchiectasis;
3. meet the criteria for an acute exacerbation of bronchiectasis with symptoms such as cough, sputum, chest tightness or wheezing, and c. Patients who meet the criteria for an acute exacerbation of bronchiectasis with symptoms of cough, sputum, chest tightness or wheezing and who consent to bronchoscopy with bronchoalveolar lavage
4. patients who agreed to participate in the study and signed an informed consent form;

Exclusion Criteria:

1. Severe cardiopulmonary diseases, coagulation disorders, poor tolerance to anaesthesia, psychiatric disorders or severe neuroses that are contraindications to bronchoscopy;
2. Intraoperative findings of decreased SPO2 or inability to tolerate bronchoscopy or inability to tolerate further bronchoalveolar lavage;
3. Inability to co-operate with the study for any reason or in the opinion of the investigator, inappropriate for inclusion in the study for other reasons;
4. Bronchoscopy of patients with significant intra-airway haemorrhage who may be at risk of exacerbation due to bronchoalveolar lavage;
5. Patients with acetylcysteine allergy;
6. Missing information;

Where it's running

• The First Affiliated Hospital of Ningbo University
  Ningbo, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Zhongbo Chen
• Email: leonczb@163.com
• Phone: 13777125910

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• How viral infections affect people with chronic lung disease

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  Recruiting Imperial College London · London · NCT06625944

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.