Using genetics and smartphone data to predict and prevent repeat suicide attempts
Prevention of Suicidal Behavior Through Therapeutic Interventions Guided by Digital Phenotype and Pharmacogenetics: The SMARTomicS Study Protocol
This project will try to combine genetic tests and people’s digital behavior to predict which individuals with a past suicide attempt may be at higher risk of trying again.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 12 Years and up |
| Sex | All |
| Sponsor | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz Academic / other |
| Locations | 1 site (Madrid, Madrid) |
| Trial ID | NCT07422090 on ClinicalTrials.gov |
What this trial studies
This is a retrospective, multi-site observational cohort that will merge genomic and metabolic profiling with digital phenotyping and clinical records in people with a lifetime history of suicide attempt. Participants (age 12 and up, with parental consent for minors) will be recruited from outpatient mental health clinics, emergency departments, and short-stay hospital units and will provide genetic samples plus consent for extraction of digital data such as Google Takeout. Investigators will link omics, prescription changes, electronic health record data, and standardized suicide-rating scales (e.g., C-SSRS) to develop predictive algorithms for suicidal behavior. Data quality checks and representativeness will be performed using hospital records and national statistics.
Who should consider this trial
Good fit: People aged 12 and older with at least one prior suicide attempt who can provide a genetic sample and give informed consent (parental consent required for ages 12–17) are the ideal candidates.
Not a fit: Those who cannot provide a blood/genetic sample or who do not consent to digital data extraction are unlikely to benefit from participation or from the predictive results.
Why it matters
Potential benefit: If successful, this approach could help clinicians identify people at higher risk of repeat suicidal behavior earlier and tailor treatments using genetic and digital signal information.
How similar studies have performed: Prior work has found some promising genetic and digital signals related to suicide risk, but fully integrated predictive models combining omics and detailed digital phenotypes remain largely experimental.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. At least one suicide attempt in their lifetime. 2. The attempt must have occurred when the participant was older than 12 years old. 3. Participants must be at least 18 years old or have parental consent if aged 12-17. Exclusion Criteria: * medical contraindication prevents blood sample collection * unable to provide informed consent to participate in the study
Where this trial is running
Madrid, Madrid
- Instituto Fundación Jiménez Díaz — Madrid, Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: Enrique Baca Garcia, Psychiatrist
- Email: ebaca@fjd.es
- Phone: +34 626932936
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.