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Clinical trial No longer in our active list Observational Ages 18 to 65

Using genetic testing to improve antidepressant prescriptions for military personnel

Official title: Evaluation of the Relevance of Pharmacogenetics in the Prescription Off Antidepressants in a Military Population

Run by Direction Centrale du Service de Santé des Armées · NCT04987047 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if genetic testing can help doctors choose the best antidepressant for military personnel dealing with depression, anxiety, and PTSD.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment250 (estimated)
SponsorDirection Centrale du Service de Santé des Armées
Academic / other
Locations4 sites (Clamart and 3 other locations)
Trial IDNCT04987047 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are military personnel aged 18 to 65 who require an antidepressant treatment and can wait 10 days for prescription.

Probably not a fit

Patients currently on antidepressants or those with contraindications to antidepressant treatment will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the role of pharmacogenetics in prescribing antidepressants to military personnel suffering from depression, anxiety, and PTSD. By analyzing genetic variants, the study aims to identify the most effective and tolerable antidepressant treatments for individuals requiring their first prescription. Participants will undergo blood collection and may complete questionnaires and cognitive tests to gather comprehensive data on their conditions and treatment responses. The goal is to reduce the time patients spend suffering from symptoms while minimizing side effects associated with ineffective treatments.

Why it matters

Potential benefit: If successful, this approach could lead to more effective and personalized antidepressant treatments for military personnel, improving their mental health outcomes.

How similar studies have gone: Other studies have shown promise in using pharmacogenetics for antidepressant prescribing, indicating potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Between 18 and 65 years-old;
* To benefit from a medical follow-up in the psychiatric department of an army training hospital;
* To present a pathology requiring an antidepressant treatment and whose prescription can wait 10 days;
* To have given written informed consent to participate in the study.

Exclusion Criteria:

* To be currently treated with an antidepressant or antidepressant stopped less than 15 days ago;
* To have one or more contraindication to the introduction of an antidepressant treatment;
* Pregnancy or breastfeeding;
* To require a measure of constraint.

Where it's running

  • Hôpital d'Instruction des Armées Percy
    Clamart, France     Recruiting
  • Hôpital d'Instruction des Armées Bégin
    Saint-Mandé, France     Recruiting
  • Hôpital d'Instruction des Armées Laveran
    Marseille, France     Not yet recruiting
  • Hôpital d'Instruction des Armées Sainte-Anne
    Toulon, France     Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Depression 1081Anxiety 603PTSD 370Direction Centrale du Service de Santé des Armées 11
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.