Using genetic testing to improve antidepressant prescriptions for military personnel
Evaluation of the Relevance of Pharmacogenetics in the Prescription Off Antidepressants in a Military Population
This study is testing if genetic testing can help doctors choose the best antidepressant for military personnel dealing with depression, anxiety, and PTSD.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Direction Centrale du Service de Santé des Armées Academic / other |
| Locations | 4 sites (Clamart and 3 other locations) |
| Trial ID | NCT04987047 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the role of pharmacogenetics in prescribing antidepressants to military personnel suffering from depression, anxiety, and PTSD. By analyzing genetic variants, the study aims to identify the most effective and tolerable antidepressant treatments for individuals requiring their first prescription. Participants will undergo blood collection and may complete questionnaires and cognitive tests to gather comprehensive data on their conditions and treatment responses. The goal is to reduce the time patients spend suffering from symptoms while minimizing side effects associated with ineffective treatments.
Who should consider this trial
Good fit: Ideal candidates are military personnel aged 18 to 65 who require an antidepressant treatment and can wait 10 days for prescription.
Not a fit: Patients currently on antidepressants or those with contraindications to antidepressant treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized antidepressant treatments for military personnel, improving their mental health outcomes.
How similar studies have performed: Other studies have shown promise in using pharmacogenetics for antidepressant prescribing, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Between 18 and 65 years-old; * To benefit from a medical follow-up in the psychiatric department of an army training hospital; * To present a pathology requiring an antidepressant treatment and whose prescription can wait 10 days; * To have given written informed consent to participate in the study. Exclusion Criteria: * To be currently treated with an antidepressant or antidepressant stopped less than 15 days ago; * To have one or more contraindication to the introduction of an antidepressant treatment; * Pregnancy or breastfeeding; * To require a measure of constraint.
Where this trial is running
Clamart and 3 other locations
- Hôpital d'Instruction des Armées Percy — Clamart, France (Recruiting)
- Hôpital d'Instruction des Armées Laveran — Marseille, France (Not_yet_recruiting)
- Hôpital d'Instruction des Armées Bégin — Saint-Mandé, France (Recruiting)
- Hôpital d'Instruction des Armées Sainte-Anne — Toulon, France (Not_yet_recruiting)
Study contacts
- Study coordinator: Emeric SAGUIN, MD
- Email: emeric.saguin@intradef.gouv.fr
- Phone: 143985440
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.