Using genetic scores to predict weight loss success in obese children
Development of Polygenic Risk Score to Predict the Efficacy of Weight Loss Intervention in Children and Adolescents With Obesity
This study is testing if genetic factors can help predict how well weight loss programs work for kids with obesity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | N/A to 18 Years |
| Sex | All |
| Sponsor | Far Eastern Memorial Hospital Academic / other |
| Locations | 1 site (New Taipei City) |
| Trial ID | NCT05466097 on ClinicalTrials.gov |
What this trial studies
This observational study aims to establish a polygenic risk score model to predict the effectiveness of weight loss interventions in children with obesity. Researchers will analyze genetic variants associated with obesity and related comorbidities through whole exome sequencing and polygenic risk score analysis. Over a 6-month weight loss program, participants will be monitored for 12-18 months to assess treatment outcomes and the impact of genetic factors on their health. The study seeks to provide a comprehensive understanding of how genetics influence weight loss success in this population.
Who should consider this trial
Good fit: Ideal candidates are children under 18 years old with obesity defined as a BMI greater than the 95th percentile for their age and gender.
Not a fit: Patients with major systemic diseases or those who consume alcohol may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized weight loss interventions for children based on their genetic profiles.
How similar studies have performed: Other studies have shown promise in using genetic approaches to tailor obesity treatments, but this specific polygenic risk score model is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \<18 years old * Obesity definition: BMI \> 95% according to the age- and gender-specific standard by National Health Institute in Taiwan * Willing to give written informed consent Exclusion Criteria: * Alcohol consumption * Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and major psychotic disorder
Where this trial is running
New Taipei City
- Far Eastern Memorial Hospital — New Taipei City, Taiwan (Recruiting)
Study contacts
- Principal investigator: Yu-Cheng Lin,, M.D., Ph.D. — Far Eastern Memorial Hospital
- Study coordinator: Yu-Cheng Lin,, M.D., Ph.D.
- Email: q92421006@ntu.edu.tw
- Phone: +886-89667000 Ext. 1723
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.