Using games to educate HIV-positive men about Hepatitis C

Reducing the Risk of Viral Hepatitis C and Other Sexually Transmitted Infections Among People Living With HIV Who Are Men Who Have Sex With Men: Efficacy of Serious Game Interventions

Not applicable Interventional National Taiwan University Hospital · NCT05751889

This study is testing whether a fun game or regular online health education can help HIV-positive men learn about Hepatitis C and change their risky sexual behaviors.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1320 (estimated)
Ages18 Years and up
SexMale
SponsorNational Taiwan University Hospital Academic / other
Locations1 site (Taipei)
Trial IDNCT05751889 on ClinicalTrials.gov

What this trial studies

This study aims to educate high-risk, HIV-positive men who have sex with men (MSM) about viral hepatitis C through two different methods: a serious game intervention and traditional online health education. Participants will be randomly assigned to either play a serious game that incorporates healthcare information about HCV or read educational materials covering similar content. Following the intervention, participants will be monitored for 48 weeks to assess changes in risky sexual behaviors and the acquisition of HCV and other sexually transmitted infections. The study will involve regular assessments through questionnaires and laboratory tests.

Who should consider this trial

Good fit: Ideal candidates for this study are high-risk MSM living with HIV who have a history of HCV infection or other sexually transmitted infections.

Not a fit: Patients who are currently HCV RNA positive and have not achieved sustained virologic response will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of viral hepatitis C among high-risk populations.

How similar studies have performed: Other studies have shown promise in using game-based interventions for health education, suggesting potential success for this novel approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* High-risk MSM living with HIV, defined as:

  1. Had prior HCV infection, and had cleared HCV through treatment or spontaneously
  2. Had any STI within the past 12 months
  3. Had any unexplained elevation of liver transaminase in the past 6 months
  4. Had at least 1 unprotected anal sex during the past 6 months
* Being able to use mobile smartphone and understand study materials
* Repeat entry of study is permitted, but the interval between health education intervention should \>52 weeks.

Exclusion Criteria:

* HCV RNA positive and yet clear virus (nor reaching SVR12).
* Admission for any acute illness (including AIDS-defining conditions)

Where this trial is running

Taipei

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Viral Hepatitis Cserious gameviral hepatitis Csexually-transmitted infectionshealth belief modelharm reductionsexualized drugsbehavioral interventions
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.