Using first-void urine for HPV testing in cervical cancer screening
Official title: Evaluation of First-void Urine as an Alternative to Cervical Sampling for Human Papillomavirus (HPV) Testing in Cervical Cancer Screening (Single-center Study).
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT06254846 · Data updated 2026-11-12
This study is testing whether using urine samples instead of traditional methods for HPV testing can help more women in France get screened for cervical cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 65 Years |
| Sex | Women only |
| Enrollment | 350 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | May 23, 2024 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT06254846 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 30 to 65 who are seeking primary cervical cancer screening.
✕Probably not a fit
Patients outside the age range of 30 to 65 or those not consulting for cervical cancer screening may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of using first-void urine samples as an alternative to traditional cervical sampling for HPV testing in cervical cancer screening. The research aims to address the low screening rates in France, where invasive cervical sampling is a significant barrier. By implementing a standardized urine collection protocol, the study seeks to determine the sensitivity of HPV PCR tests on urine samples and assess the acceptability of this method through participant questionnaires.
Why it matters
Potential benefit: If successful, this approach could make cervical cancer screening more accessible and comfortable for women.
How similar studies have gone: While some studies have explored urine testing for HPV, this specific approach with standardized collection is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * Age between 30 and 65 * Consulting in the Gynecology-Obstetrics department for primary cervical cancer screening * Patient affiliated or entitled to a social security regimen * Patient who has received information about the study and expressed non-opposition Exclusion Criteria: \-
Where it's running
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Service de Gynécologie Obstétrique - CHU Saint-Etienne
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: Louise MONIOD, MD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Louise MONIOD, MD
- Email: louise.moniod@chu-st-etienne.fr
- Phone: (0)4 77 82 83 83
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.