Using fecal microbiota transplantation to treat various diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment for a range of diseases associated with dysbiosis, including gastrointestinal disorders, autoimmune diseases, and metabolic conditions. FMT involves infusing feces from a healthy donor into the gastrointestinal tract of a patient to restore a balanced microbiome. The study aims to gather more data on the effectiveness of FMT for these conditions, which is still in the early stages of research. Participants will be monitored for safety and treatment outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Confirmed diagnosis of any of following diseases:

* Irritable Bowel Syndrome
* Ulcerative colitis
* Crohn's disease
* Constipation
* Clostridium Difficile Infection
* Functional Dyspepsia
* Parkinson's Disease
* Metabolic Syndrome
* Non-Alcoholic Fatty Liver Disease
* Autism Spectrum Disorder
* Radiation Enteritis
* Atopic Dermatitis
* Food Allergic
* Graft-versus-Host Disease
* Obesity
* Diabetes mellitus
* Multi-Drug Resistant Infection
* Hepatic Encephalopathy
* Enteric Dysbacteriosis
* Multiple Sclerosis
* Pseudomembranous Enteritis
* Acute Pancreatitis
* Chronic Fatigue Syndrome
* Acute-on-chronic Liver Failure with HBV Infection
* Alcoholic Liver Disease
* Anorexia
* Decompensated Cirrhosis
* Henoch-Schonlein Purpura
* Autoimmune Liver Disease
* Systemic Lupus Erythematosus
* Rheumatoid arthritis
* IgG4-Related Disease
* Celiac Disease
* Protein-losing Enteropathy
* Asperger Syndrome
* Rheumatoid arthritis
* Psoriasis
* Ankylosing spondylitis
* Immune checkpoint inhibition-related colitis
* Autoimmune enteropathy
* Drug-induced diarrhea
* Suffering from gastrointestinal symptoms such as constipation, diarrheas, abdominal pain, flatulence, etc.
* The participants must be able to tolerate the FMT infusion method such as endoscopy, colonoscopy, capsule, nasoduodenal tube insertion, etc.

Exclusion Criteria:

* Current pregnancy or breast-feeding;
* Suffering from other severe diseases, including liver or kidney failure, heart failure, MODS, coma, cerebrovascular accident;
* Known contraindication to all FMT infusion method such as nasoduodenal tube insertion, endoscopy, colonoscopy and enema;
* Any conditions that may render the efficacy of FMT or at the discretion of the investigators.

Where it's running

• Guangzhou First People's Hospital
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Hongli Huang, MM — Guangzhou First People's Hospital
• Study coordinator: Yongjian Zhou, MM
• Email: eyzhouyongjian@scut.edu.cn
• Phone: 86-13503060150

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Fecal transplant plus standard therapy for refractory hepatic encephalopathy after TIPS

  This study tests whether adding fecal microbiota transplantation to usual medicines helps people with recurrent hepatic encephalopathy after TIPS implant.

  Recruiting Early Phase 1 Air Force Military Medical University, China · Xi'an · NCT07683936

• Using fecal microbiota transplantation to prevent infections after liver transplantation

  This study is testing if a special treatment using healthy stool can help prevent infections in people getting a liver transplant.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06782880

• Maternal fecal transplant for babies born by cesarean section

  This trial will try giving a small fecal transplant from the mother to newborns delivered by elective C-section to see if it improves their gut microbiome and lowers the risk of later overweight or obesity.

  Recruiting Oulu University Hospital · Oulu · NCT06282952

• Using fecal microbiota transplantation to reduce colorectal adenoma recurrence

  This study tests if a treatment using healthy gut bacteria can help prevent the return of colorectal adenomas in patients who have had them removed.

  Recruiting Phase 2 Shenzhen Hospital of Southern Medical University · Guangzhou, Guangdong and 4 other locations · NCT06205862

• Using fecal transplantation to eliminate drug-resistant bacteria

  This study is testing whether using fecal transplants can help adults get rid of harmful drug-resistant bacteria in their gut.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Clichy and 10 other locations · NCT05035342

• Restoring gut bacteria in patients with Crohn's disease

  This study is testing whether a treatment using healthy gut bacteria can help people with active Crohn's disease feel better.

  Recruiting Phase 1/2 St Vincent's Hospital Melbourne · Melbourne, Victoria · NCT04970446

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.