Using Extracorporeal Membrane Oxygenation for Severe Poisoning Treatment

Treatment of Extracorporeal Membrane Oxygenation in Severe Poisoning

This study is testing if using a special oxygen machine called ECMO can help critically ill patients recover from severe poisoning by improving their organ function and removing toxins from their bodies.

Quick facts

• Study type: Observational
• Enrollment: 60 (estimated)
• Ages: 14 Years and up
• Sex: All
• Sponsor: Affiliated Hospital of Nantong University (other)
• Locations: 1 site (Nantong, Jiangsu)
• Trial ID: NCT05762029 on ClinicalTrials.gov

What this trial studies

This prospective multicenter observational study aims to evaluate the effectiveness of Extracorporeal Membrane Oxygenation (ECMO) in critically ill patients suffering from severe poisoning. The study will include 60 patients and will analyze their blood and urine samples to assess organ function and toxin removal during ECMO treatment. It seeks to determine the optimal use of ECMO, including timing, mode, and potential combination with blood purification methods. The findings may provide crucial insights into the management of poisoning cases requiring advanced life support.

Who should consider this trial

Good fit: Ideal candidates are patients experiencing severe intoxication leading to cardiac arrest, refractory shock, or respiratory failure who have no other treatment options.

Not a fit: Patients with severely impaired consciousness prior to cardiac arrest or those with multiple organ dysfunction may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve treatment protocols for patients with severe poisoning, potentially saving lives.

How similar studies have performed: While ECMO has been used in various critical care settings, this specific application in severe poisoning is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

* Severe intoxication resulting in cardiac arrest, refractory malignant arrhythmia, refractory shock, refractory heart failure, respiratory failure.
* Denying other available methods.
* Indications for the use of the Extracorporeal membrane oxygenation exist.

Exclusion Criteria:

* Severely impaired state of consciousness prior to cardiac arrest;
* Multiple organ dysfunction;
* Uncontrolled traumatic bleeding, massive gastrointestinal bleeding, and active intracranial hemorrhage;
* Left ventricular thrombosis; Severe aortic insufficiency.

Where this trial is running

Nantong, Jiangsu

• Affiliated Hospital of Nantong University — Nantong, Jiangsu, China (RECRUITING)

Study contacts

• Study coordinator: Zhongwei Huang, Master

Conditions: Poison, Medicinal, Extracorporeal Membrane Oxygenation, Severe poisoning, Emergency medical care