Using Exparel and education to reduce opioid use after carpal tunnel surgery
Exparel and Education to Avoid Opioids After Carpal Tunnel Release
PHASE4 · Kettering Health Network · NCT03867539
This study is testing if using Exparel along with education on opioid use can help people have less pain and use fewer opioids after carpal tunnel surgery.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kettering Health Network (other) |
| Locations | 2 sites (Dayton, Ohio and 1 other locations) |
| Trial ID | NCT03867539 on ClinicalTrials.gov |
What this trial studies
This trial investigates the use of Exparel, a long-acting local anesthetic, combined with opioid education to minimize post-operative opioid consumption following carpal tunnel release surgery. Participants will be divided into two groups: one receiving Exparel and opioid education, and the other receiving standard care with non-liposomal bupivacaine, opioid education, and opioids. The study aims to address the opioid epidemic by exploring alternative pain management strategies and changing public perceptions regarding post-operative pain expectations. The findings could provide evidence for a new standard of care in managing pain after this common procedure.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 diagnosed with carpal tunnel syndrome.
Not a fit: Patients with a history of opioid use in the last six months or allergies to bupivacaine or related medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce reliance on opioids for pain management after carpal tunnel surgery.
How similar studies have performed: While there is limited data on the use of long-acting local analgesia in hand surgery, the approach of combining it with opioid education is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * carpal tunnel syndrome diagnosed either by physical exam or EMG * age \>18. Exclusion Criteria: * allergy to bupivacaine * pre-operative opioid usage within the last six months * patients allergic to Percocet or acetaminophen * patients taking tricyclic antidepressants (interaction with bupivacaine) * vulnerable populations (prisoners or pregnant women)
Where this trial is running
Dayton, Ohio and 1 other locations
- Orthopedic Associates of Southwest Ohio — Dayton, Ohio, United States (RECRUITING)
- Orthopedic Associates of Southwest Ohio — Dayton, Ohio, United States (RECRUITING)
Study contacts
- Principal investigator: Ronald Buczek, DO — Kettering Health Network
- Study coordinator: Ronald Buczek, DO
- Email: orthostudy2019@gmail.com
- Phone: 937-439-6483
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Carpal Tunnel Syndrome, hand, exparel, opioid crisis