Using exosomes to modulate the immune response in critically ill COVID-19 patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the immune-modulating effects of exosomes derived from mesenchymal stem cells in critically ill patients suffering from COVID-19. By stimulating whole blood samples from these patients, the study aims to analyze immune phenotypes, cytokine release, and mRNA expression patterns. The goal is to understand how these exosomes can potentially reduce inflammation and support anti-fibrotic pathways in patients experiencing severe lung dysfunction due to COVID-19.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Critically ill COVID-19 patients with lung dysfunction
* COVID-19 WHO severity degree \>= 4, ARDS (WHO Definition 13 March 2020)
* Body weight \> 50 kg
* Informed consent

Exclusion Criteria:

* Pregnant or breast feeding women

Where it's running

• Ulm University Hospital, Clinic of Anesthesiology and Intensive Care Medicine
  Ulm, Germany Recruiting

Study contacts

• Principal investigator: Manfred Weiss, MD — Clinic of Anaesthesiology and Intensive Care Medicine
• Study coordinator: Manfred Weiss, MD
• Email: manfred.weiss@uniklinik-ulm.de
• Phone: +49(0)731500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.