Using exosome microRNAs to identify metabolic bone disease in premature infants
Official title: Prospective Cohort Study of Exosomal microRNAs as Biomarkers for Diagnosis and Therapeutic Efficacy Evaluation of Metabolic Bone Diseases in Premature Infants
Run by Hunan Children's Hospital · NCT06368154 · Data updated 2026-11-12
This study is trying to see if tiny particles in the blood of premature babies can help doctors spot a serious bone disease early on.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Hours to 72 Hours |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Hunan Children's Hospital Government |
| Locations | 1 site (Changsha, Hunan) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | April 16, 2024 |
| Trial ID | NCT06368154 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are preterm infants aged less than 28 days with a gestational age between 37 and 41 weeks.
✕Probably not a fit
Patients who have undergone blood transfusions, surgeries, or have congenital malformations or inherited metabolic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the potential of exosome microRNAs as biomarkers for metabolic bone disease of prematurity (MBDP) in preterm infants. MBDP is a serious condition characterized by insufficient calcium and phosphorus, leading to complications in bone health. The study will analyze plasma exosomes from preterm infants to identify specific microRNAs that could serve as early diagnostic markers for this condition. By focusing on infants with a gestational age of 37 to 41 weeks and under 28 days old, the research seeks to improve early detection methods for MBDP.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate diagnosis of metabolic bone disease in premature infants, potentially improving their health outcomes.
How similar studies have gone: Previous studies have shown promise in using plasma or serum microRNAs as molecular markers for early prediction of bone diseases, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * The gestational age was 37+0-41+6 weeks and the age was less than 28 days Exclusion Criteria: * There was no blood transfusion, no operation, no congenital malformation, no inherited metabolic diseases, no history of intravenous nutrition, and no intestinal diseases
Where it's running
-
Hunan Children's Hospital
Changsha, Hunan, China Recruiting
Study contacts
- Study coordinator: yinzhi Y liu, master
- Email: liuyinzhi0837@163.com
- Phone: 13467532228
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Dry Cord Care vs Alcohol Cord Care for Healthy Newborns
This trial tests whether dry cord care or routine alcohol cord care is better for healthy newborns by looking at infection rates in the umbilical cord.
-
Breathing before breastfeeding to help moms of NICU babies
This study tests whether pre-breastfeeding breathing exercises can reduce anxiety and improve well-being for mothers with babies in the NICU.
-
Intratympanic dexamethasone‑loaded exosomes versus standard ear steroid injections for sudden sensorineural hearing loss
This will test whether a single intratympanic injection of dexamethasone carried by exosomes improves hearing more than standard intratympanic dexamethasone or exosome‑only injections in adults with recent sudden sensorineural hearing loss who failed oral steroids.
-
Co‑dodo crib use to improve maternal–newborn sleep and bonding in the maternity ward
This study tests whether using a co‑dodo crib during the hospital postpartum stay helps full‑term, exclusively breastfeeding mothers and their newborns sleep better and bond more than a standard crib.
-
Does giving IV fluids to mothers before birth change how much a newborn loses weight in the first days?
This project sees if the amount of IV fluids a mother receives before delivery affects weight loss in formula-fed newborns during their first two days of life.
-
Reducing heel‑prick pain and improving comfort in newborns with Buzzy or ShotBlocker
This test tries whether using a small vibrating device (Buzzy) or a pressure device (ShotBlocker) before and after a heel prick can reduce pain and improve comfort for full‑term newborns.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.