Using exosome microRNAs to identify metabolic bone disease in premature infants
Prospective Cohort Study of Exosomal microRNAs as Biomarkers for Diagnosis and Therapeutic Efficacy Evaluation of Metabolic Bone Diseases in Premature Infants
Hunan Children's Hospital · NCT06368154
This study is trying to see if tiny particles in the blood of premature babies can help doctors spot a serious bone disease early on.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 0 Hours to 72 Hours |
| Sex | All |
| Sponsor | Hunan Children's Hospital (other gov) |
| Locations | 1 site (Changsha, Hunan) |
| Trial ID | NCT06368154 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the potential of exosome microRNAs as biomarkers for metabolic bone disease of prematurity (MBDP) in preterm infants. MBDP is a serious condition characterized by insufficient calcium and phosphorus, leading to complications in bone health. The study will analyze plasma exosomes from preterm infants to identify specific microRNAs that could serve as early diagnostic markers for this condition. By focusing on infants with a gestational age of 37 to 41 weeks and under 28 days old, the research seeks to improve early detection methods for MBDP.
Who should consider this trial
Good fit: Ideal candidates for this study are preterm infants aged less than 28 days with a gestational age between 37 and 41 weeks.
Not a fit: Patients who have undergone blood transfusions, surgeries, or have congenital malformations or inherited metabolic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate diagnosis of metabolic bone disease in premature infants, potentially improving their health outcomes.
How similar studies have performed: Previous studies have shown promise in using plasma or serum microRNAs as molecular markers for early prediction of bone diseases, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The gestational age was 37+0-41+6 weeks and the age was less than 28 days Exclusion Criteria: * There was no blood transfusion, no operation, no congenital malformation, no inherited metabolic diseases, no history of intravenous nutrition, and no intestinal diseases
Where this trial is running
Changsha, Hunan
- Hunan Children's Hospital — Changsha, Hunan, China (RECRUITING)
Study contacts
- Study coordinator: yinzhi Y liu, master
- Email: liuyinzhi0837@163.com
- Phone: 13467532228
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Exosomes, Newborn, Bone Diseases, Metabolic