Using exhaled breath particles to detect lung transplant rejection
Exhaled Breath Particles as a Clinical Indicator for Acute and Chronic Rejection After Lung Transplantation
Lund University Hospital · NCT05375149
This study is testing if measuring tiny particles in the breath of lung transplant patients can help spot early signs of rejection to improve their treatment and survival.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 16 Years to 75 Years |
| Sex | All |
| Sponsor | Lund University Hospital (other) |
| Locations | 1 site (Lund, Skåne County) |
| Trial ID | NCT05375149 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients who have undergone lung transplantation at Skåne University Hospital. It aims to utilize non-invasive measurements of exhaled breath particles (EBP) and particle flow rate (PFR) to detect early signs of lung transplant rejection. Patients will have their EBP and PFR measured multiple times post-transplant, alongside blood samples and bronchoalveolar lavage fluid collection during routine follow-ups. The goal is to identify rejection earlier and explore potential biomarkers that could improve treatment and survival rates.
Who should consider this trial
Good fit: Ideal candidates are patients who have recently undergone lung transplantation at Skåne University Hospital.
Not a fit: Patients who have not undergone lung transplantation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of lung transplant rejection, improving treatment options and patient survival.
How similar studies have performed: Previous studies have shown promise in using exhaled breath particles for monitoring airway diseases, suggesting potential success for this novel approach in lung transplantation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have undergone LTx at Skåne University Hospital, SUS Lund Exclusion Criteria: * None
Where this trial is running
Lund, Skåne County
- Skåne University Hospital — Lund, Skåne County, Sweden (RECRUITING)
Study contacts
- Principal investigator: Sandra Lindstedt, MD, PhD — Region Skåne, Lund University
- Study coordinator: Sandra Lindstedt, MD, PhD
- Email: sandra.lindstedt_ingemansson@med.lu.se
- Phone: +46737220580
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Lung Transplant Rejection, Primary Graft Dysfunction, Chronic Rejection of Lung Transplant, Exhaled Breath Particles, PExA, Lung transplantation, Chronic Lug Allograft Dysfunction