Using epinephrine to prevent complications after intubation in ICU patients with shock
Intravenous Epinephrine Bolus for Prevention of Postintubation Collapse in Intensive Care Septic Patients Predicted by Shock Index.
This study is testing if giving epinephrine can help prevent complications after intubation in ICU patients with shock.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06115473 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of intravenous epinephrine to prevent post-intubation collapse in septic patients who are experiencing shock. It is a randomized prospective comparative study conducted in the intensive care units of Ain Shams University Hospitals. The study will enroll 44 patients who meet specific inclusion criteria, including a shock index greater than 0.9, and will randomly assign them to receive either epinephrine or isotonic fluid. The goal is to assess the effectiveness of epinephrine in maintaining hemodynamic stability after emergency intubation.
Who should consider this trial
Good fit: Ideal candidates for this study are septic patients over 18 years old who require emergent intubation and have a shock index greater than 0.9.
Not a fit: Patients who may not benefit from this study include those under 18, pregnant individuals, and those with contraindications to epinephrine or a shock index below 0.9.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of post-intubation hypotension and improve outcomes for critically ill patients.
How similar studies have performed: While the use of push-dose pressors is common, this specific application of epinephrine for preventing post-intubation complications in septic patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * septic patients of either sex above 18 years of age, will need emergent intubation during ICU admission, shock index (SI) \> 0.9. Exclusion Criteria: * patient's family refusal, age \<18, pregnant, Patients with tachyarrhythmias, traumatic patients, patient with shock index \<0.9, ischemic heart patients, any comorbidities contraindicated to take epinephrine and allergic to epinephrine will be excluded from the study.
Where this trial is running
Cairo
- Ain Shams University Hospitals at Intensive care units department — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.