Using entropy to detect sleep breathing problems in chronic lung disease
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
This project will test whether entropy measurements from simple overnight oxygen and pulse recordings can find sleep-disordered breathing in adults with chronic lung conditions such as COPD, asthma, bronchiectasis, and interstitial lung disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University College, London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT07060079 on ClinicalTrials.gov |
What this trial studies
The study applies nonlinear entropy analysis (for example, sample entropy) to physiological signals such as oxygen saturation and pulse rate recorded overnight with portable monitors. Researchers will compare entropy measures between adults with chronic respiratory diseases who do and do not have sleep-disordered breathing to identify characteristic differences. The approach aims to determine whether relatively simple finger pulse oximetry can provide useful screening information versus full cardiorespiratory testing. If successful, this method could clarify complex interactions between heart rate and oxygen signals during sleep in this patient group.
Who should consider this trial
Good fit: Adults (age 18 and over) with chronic respiratory disease (COPD, asthma, bronchiectasis, or interstitial lung disease) who can give informed consent and are willing to sleep with portable monitoring devices are ideal candidates.
Not a fit: Children, people unable to use portable monitoring or give consent, and patients with contraindications to portable monitoring or who require full in-lab testing for complex sleep disorders are unlikely to benefit from this screening approach.
Why it matters
Potential benefit: If successful, this method could allow earlier or simpler detection of sleep-disordered breathing using low-burden overnight oximetry instead of full polysomnography for some patients.
How similar studies have performed: Entropy and other nonlinear metrics have shown promise in cardiovascular research and some sleep-oximetry screening work, but their application specifically to obstructive sleep apnoea in chronic respiratory disease is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients (≥ 18years) with chronic respiratory disease with/without SDB. * patients who have had previously negative studies as a control group. * Subject is able to read, understand, and sign the informed consent form. * Willing to sleep with portable monitoring devices. Exclusion Criteria: * Patients who are under 18 years of age at the time of the index study. * Contraindications to the use of portable monitoring. * Inability to give informed consent to take part in the study.
Where this trial is running
London
- Royal Free hospital — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Nawal Alotaibi
- Email: n.alotaibi@ucl.ac.uk
- Phone: 02080168375
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.