Using electrical impedance tomography to assess lung pressure in patients with acute respiratory distress syndrome
Pressure Opening With Electrical Impedance Tomography
This study is testing a new way to use electrical signals to check lung pressure in patients with acute respiratory distress syndrome to see if it can help improve their breathing treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Amiens) |
| Trial ID | NCT05825534 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of electrical impedance tomography (EIT) to monitor lung function in patients suffering from acute respiratory distress syndrome (ARDS) and acute lung injury. By measuring regional changes in lung compliance and airway opening pressure, the study aims to improve mechanical ventilation strategies. The approach involves performing a pressure-volume curve analysis with a low-flow insufflation technique to gather data on lung behavior during ventilation. This non-invasive method could provide critical insights into optimizing treatment for affected patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients aged 18 and older with a PaO2/FiO2 ratio less than 300 mmHg who are undergoing volume- or pressure-controlled ventilation.
Not a fit: Patients with severe hemodynamic instability, pneumothorax, or contraindications to EIT will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved mechanical ventilation strategies for patients with ARDS, potentially enhancing their recovery and outcomes.
How similar studies have performed: Previous studies have suggested that similar approaches using EIT for monitoring lung function have shown promise, indicating potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥18 years old). * Patients with PaO2/FiO2 ratio \<300 mmHg. * Volume- or pressure-controlled ventilation. * Sedated, with or without infusion of neuromuscular blockage. * Patients in supine position Exclusion Criteria: * Pneumothorax and bronchopleural fistula. * Severe hemodynamic instability (\>30 % increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min). * PaO2/FiO2 ratio \< 80 mmHg. * Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \< 30 % predicted). * Known or highly suspected elevated intracranial pressure (\>18 mmHg). * Impossibility to correctly position the EIT belt (e.g., burns chest drainage, etc.). * Contraindications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions, etc.). * Clinical judgement of the attending physician. * Pregnant or breastfeeding woman * Patient under guardianship, curators or safeguard of justice
Where this trial is running
Amiens
- CHU Amiens — Amiens, France (Recruiting)
Study contacts
- Study coordinator: Clément Brault, MD
- Email: brault.clement@chu-amiens.fr
- Phone: 03 22 08 89 09
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.