Using electrical cardioversion to improve heart rhythm after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the benefits of electrical cardioversion in patients with persistent atrial fibrillation who have undergone radiofrequency catheter isolation of pulmonary veins. It aims to determine if electrical cardioversion can lead to reverse remodeling of the left atrium and reduce fibrosis, potentially predicting freedom from atrial fibrillation after catheter ablation. Participants will be monitored through echocardiography and 24-hour ECG assessments at multiple follow-up points post-surgery. The study focuses on understanding the long-term effects of this intervention on heart rhythm preservation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Informed consent signed by the patient to participate in the study.
* Persistent atrial fibrillation resistant to antiarrhythmic drugs for 6 months or more
* The size of the left atrium is less than 55 mm, volume is less than 130 ml, volume index (LP) is less than 55 ml/m2

Exclusion Criteria:

* Reversible causes of atrial fibrillation (hyperthyroidism, pericarditis, myocarditis).
* Patients in need of myocardial revascularization and/or heart valvular disease correction.
* Any previous intervention (including MAZE surgery, thoracoscopic ablation; implanted occluder of the auricle of the left atrium.).
* Patients with severe concomitant pathology requiring correction.
* Contraindications for administration of anticoagulant therapy.
* Documented presence of a blood clot in the cavity of the left atrium or other reasons preventing the insertion of catheters into the left atrium.
* BMI of 40 or more

Where it's running

• Saint Petersburg State University Clinic
  Saint Petersburg, Sankt-Peterburg, Russia Recruiting

Study contacts

• Study coordinator: Anton A Sheremet, MD
• Email: sheremet.dr@yandex.ru
• Phone: +79313084398

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ablation of focal activation in atrial fibrillation

  This study is testing a new method to find specific electrical signals that may be causing ongoing atrial fibrillation in patients, to see if targeting these signals can improve their treatment.

  Recruiting Imperial College London · London · NCT06402617

• New ablation technique for persistent atrial fibrillation

  This study is testing a new treatment for people with persistent atrial fibrillation to see if a combination of techniques can help them feel better and have fewer heart problems compared to standard care.

  Recruiting Second Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06249347

• Hybrid ablation for treating persistent atrial fibrillation

  This study is testing a new hybrid treatment for people with persistent atrial fibrillation to see if it works better than the standard catheter procedure in helping them stay free from heart rhythm problems.

  Recruiting at 5 sites St. George's Hospital, London · Chertsey and 6 other locations · NCT05411614

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities

  This study tests how comorbid conditions like sleep apnea and primary aldosteronism relate to left-atrial fibrosis and AF recurrence in patients undergoing ablation.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT07857044

• Dual Energy ablation with SmartTouch SF catheter in persistent atrial fibrillation

  This study tests a pulsed field and radiofrequency ablation system to treat persistent atrial fibrillation in adults who have not responded well to prior medications.

  Recruiting at 4 sites Biosense Webster, Inc. · Beijing and 3 other locations · NCT07845682

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.