Using echocardiography to improve fluid management in septic shock patients
Official title: Impact of an Echographic Algorithm on Hemodynamic Optimization in the First 4 Days of Septic Shock Management: a Multicentric, Randomized, Controlled, Open Label Pilot-study
Run by Centre Hospitalier Universitaire de Nīmes · NCT06043505 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if using ultrasound to guide fluid treatment can help critically ill patients with septic shock feel better and avoid complications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 136 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nīmes Academic / other |
| Locations | 1 site (Nîmes) |
| Trial ID | NCT06043505 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who develop septic shock while in an intensive care unit.
✕Probably not a fit
Patients with conditions such as cardiac tamponade, infective endocarditis, or severe dilated cardiomyopathy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of an echocardiographic algorithm in optimizing hemodynamic management during the first four days of treatment for patients with septic shock. By utilizing transthoracic echocardiography and lung ultrasound, the study aims to enhance fluid resuscitation strategies and reduce the risks associated with fluid overload and hypovolemia. The trial is multicenter and randomized, focusing on critically ill patients in intensive care units who meet specific inclusion criteria. The goal is to determine whether this echographic approach can lead to better patient outcomes in septic shock management.
Why it matters
Potential benefit: If successful, this approach could significantly improve fluid management and reduce mortality rates in patients experiencing septic shock.
How similar studies have gone: While the use of echocardiography in hemodynamic assessment is established, this specific approach to optimizing fluid management in septic shock is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
All eligible patients will have a cardiac echocardiogram prior to inclusion for the sole purpose of eliminating special situations that are part of the non-inclusion criteria listed below. Inclusion Criteria * Patient in an intensive care unit who develops septic shock on admission or during hospitalization, as defined by SEPSIS-3 criteria. * Patient or trusted person / legal representative / family member / curator / guardian who has given free and informed consent and has signed the consent form or patient included in an emergency situation. * Patient affiliated or beneficiary of a health insurance plan. * Patient at least (≥) 18 years of age. Exclusion Criteria: * Refusal of consent. * Patient under court protection or guardianship. * Moribund patient with a life expectancy of less than 48 hours. * Non-echogenic patient. * Cardiac tamponade. * Infective endocarditis. * Intracavitary thrombus. * Dilated cardiomyopathy with LVEF (Left Ventricular Ejection Fraction\<40%. * Parturient or nursing patient.
Where it's running
-
CHU de Nimes
Nîmes, France Recruiting
Study contacts
- Principal investigator: Claire Roger — CHU Nimes
- Study coordinator: Claire Roger, MD
- Email: Claire.roger@chu-nimes.fr
- Phone: 04.66.68.30.50
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.