Using Echocardiography to Detect Acute Coronary Syndrome in Emergency Patients
Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study
This study is testing if a special heart imaging technique can help doctors quickly identify acute coronary syndrome in adults with chest pain in the emergency room.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Locations | 1 site (Bruxelles) |
| Trial ID | NCT06860997 on ClinicalTrials.gov |
What this trial studies
This prospective observational study aims to evaluate the effectiveness of tissue Doppler imaging (TDI) S' wave velocity as a diagnostic tool for acute coronary syndrome (ACS) in adults presenting with acute chest pain in the emergency department. The study will compare the diagnostic performance of TDI S' wave with other echocardiographic markers and assess how demographic factors may influence these results. Patients aged 18 and older who do not show ST-elevation myocardial infarction (STEMI) on their initial ECG and require continuous cardiac monitoring will be included. The findings will be compared against final diagnoses to determine the accuracy of TDI S' wave in identifying ACS.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older presenting to the emergency department with acute chest pain and no STEMI on their initial ECG.
Not a fit: Patients with known pre-existing cardiomyopathy, severe valvular heart disease, or those presenting with non-cardiac causes of chest pain may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate diagnosis of acute coronary syndrome, potentially improving patient outcomes.
How similar studies have performed: Other studies have explored echocardiographic markers for ACS, but the specific use of TDI S' wave is a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Presenting to the emergency department (ED) with acute chest pain * No ST-elevation myocardial infarction (STEMI) on initial ECG * Requiring continuous cardiac monitoring based on triage decision * Able to provide informed consent (written consent required) Exclusion Criteria: * Known pre-existing cardiomyopathy (e.g., hypertrophic cardiomyopathy, dilated cardiomyopathy) * Severe valvular heart disease * Left bundle branch block (LBBB) or presence of a pacemaker * Arrhythmias (e.g., atrial fibrillation, frequent premature ventricular contractions) * Cardiac arrest or cardiogenic shock at presentation * Pulmonary hypertension * Pericardial effusion or tamponade * Non-cardiac cause of chest pain suspected as the primary diagnosis * Language barrier preventing informed consent (study materials available in English, French, and Dutch)
Where this trial is running
Bruxelles
- Cliniques Universitaires Saint-Luc — Bruxelles, Belgium (Recruiting)
Study contacts
- Principal investigator: Bastian Rodrigues de Castro, MD — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Study coordinator: Bastian Rodrigues de Castro, MD
- Email: bastian.rodrigues@saintluc.uclouvain.be
- Phone: +32498236523
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.