Using Duloxetine and Tramadol to Treat Chronic Cancer Pain
Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain
This study is testing whether a combination of duloxetine and tramadol can help people with chronic cancer pain feel better while reducing the need for traditional opioids.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Assiut) |
| Trial ID | NCT05311774 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of combining duloxetine, a serotonin norepinephrine reuptake inhibitor, with tramadol, a non-opioid analgesic, for managing chronic cancer pain. The approach aims to address both nociceptive and neuropathic pain components often experienced by cancer patients. By utilizing a combination of these medications, the study seeks to reduce reliance on traditional opioids and their associated side effects. Patients will be monitored for pain relief and any adverse effects during the treatment period.
Who should consider this trial
Good fit: Ideal candidates are cancer patients aged 20 to 70 who are opioid naïve and not currently receiving any analgesic treatment.
Not a fit: Patients who have contraindications for duloxetine or tramadol or those who are difficult to assess for pain may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a safer and more effective pain management option for cancer patients.
How similar studies have performed: While the combination of duloxetine and tramadol has been explored in other contexts, this specific approach for chronic cancer pain is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with cancer pain 1. age from 20-70 years old. 2. not receiving any type of analgesia before (opioid naïve, no adjuvants). Exclusion Criteria: 1. Difficult to be assessed for pain. 2. Any contraindication for duloxetine or tramadol.
Where this trial is running
Assiut
- Assiut University — Assiut, Egypt (Recruiting)
Study contacts
- Study coordinator: Madona M Noman, master
- Email: madonamisheal90@yahoo.com
- Phone: 201006265867
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.