Using Doppler ultrasound to assess fetal kidney blood flow in preeclampsia cases
Fetal Renal Artery Doppler in Patients With Preeclampsia and Its Role in Prediction of Adverse Neonatal Outcomes
This study is testing how using Doppler ultrasound to check blood flow in the kidneys of fetuses can help understand the effects of preeclampsia on their health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 88 (estimated) |
| Sex | Female |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Assiut) |
| Trial ID | NCT06395974 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the use of Doppler ultrasound to evaluate renal artery blood flow in fetuses of women diagnosed with preeclampsia after 28 weeks of pregnancy. It aims to understand how placental insufficiency affects fetal blood distribution to vital organs, particularly the kidneys, compared to healthy pregnancies. By examining the vascular resistance and blood flow patterns, the study seeks to identify potential hemodynamic changes associated with preeclampsia. The findings could provide insights into the management of pregnancies affected by this condition.
Who should consider this trial
Good fit: Ideal candidates include women with preeclampsia after 28 weeks of pregnancy and those with healthy singleton pregnancies matched by gestational age.
Not a fit: Patients with multiple pregnancies, known congenital fetal malformations, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve monitoring and management strategies for pregnancies affected by preeclampsia, potentially enhancing fetal outcomes.
How similar studies have performed: While the use of Doppler ultrasound in assessing fetal blood flow is established, this specific application in preeclampsia is less common, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* a) Preeclampsia:
* Women with preeclampsia \>28 weeks of pregnancy.
* Singleton pregnancy.
* Women with intrauterine growth restriction and abnormal amniotic fluid volume to simulate real world data.
b) Control:
* Women with healthy pregnancy matched by closest gestational age.
Exclusion Criteria:
* ● Multiple pregnancy.
* Known Congenital fetal malformations.
* Women with other comorbidity such as ischemic heart disease, DM, Autoimmune disorders, kidney disease, neurological disorders, liver or haematological disorders.
* Women unable to provide informed consent.
* Women who refuse to participate
Where this trial is running
Assiut
- Assiut university hospital — Assiut, Egypt (Recruiting)
Study contacts
- Principal investigator: Yousra O Mokhtar — principle investigator
- Study coordinator: Yousra O Mokhtar
- Email: yousramo5tar@gmail.com
- Phone: +201064990954
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.