Using dobutamine to help surgical patients with septic shock
Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor
This study is testing if giving dobutamine can help surgical patients with septic shock feel better and improve their heart function during treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 584 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | First Affiliated Hospital of Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06462313 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of dobutamine on surgical patients experiencing septic shock, a severe condition characterized by extremely low blood pressure despite fluid resuscitation. The study aims to determine if dobutamine can improve cardiac function and overall clinical outcomes in these patients undergoing general anesthesia. Given the high incidence of septic shock-related cardiomyopathy and the limitations of current treatments, this trial seeks to provide evidence for a potentially beneficial intervention. The approach involves administering dobutamine alongside norepinephrine to enhance tissue perfusion and myocardial contractility.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are undergoing surgery and experiencing septic shock with an operation duration of more than one hour.
Not a fit: Patients who are pregnant, have certain pre-existing conditions, or have recently used specific medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cardiac function and reduced mortality in surgical patients with septic shock.
How similar studies have performed: While the combined use of norepinephrine and dobutamine has been recommended in guidelines, no randomized controlled trials have yet explored this specific approach in surgical patients with septic shock, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with 18 years or older 2. Sugery patients with septic shock and the duration of opration is more than 1 hour Exclusion Criteria: 1. Pregnancy; 2. Long-term intakeβ-receptor blocker; 3. patietns with dobutamine used within 72h before enrollment; 4. Patients use Recombinant Human Brain Natriuretic Peptide(rhBNP), Levosimendan and Epinephrine within 72h before enrollment; 5. Patients with hyperthyroidism; 6. Allergy or known sensitivity to catecholamines（norepinephrine, dobutamine etc.）and genera anesthetics. 7. Patients and guardians refused to participate in this intervention clinical trial.
Where this trial is running
Hangzhou, Zhejiang
- The First Affiliated Hospital, School of Medicine, Zhejiang University — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Xiangming Fang, Doctor
- Email: xmfang@zju.edu.cn
- Phone: 13867161019
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.