Using different sodium hypochlorite concentrations in root canal retreatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, single-center trial enrolling adults who require non-surgical root canal retreatment. After removal of previous root filling material, intracanal fluid samples are taken before and after irrigation with one of three sodium hypochlorite concentrations (1%, 2.5%, 5.25%). Neuropeptide levels (Substance P, CGRP, Opiorphin) will be quantified by ELISA, and patients will record postoperative pain using a visual analog scale at predefined time points. The study compares biochemical changes in the canal with clinical pain outcomes to clarify links between irrigant concentration, inflammatory mediators, and pain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 65 years.
* Systemically healthy individuals (ASA I or II)
* Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
* Patients who provide written informed consent.

Exclusion Criteria:

* Patients with systemic diseases that may affect pain perception or inflammatory response.
* Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment.
* Pregnant or lactating women.
* Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth.
* Teeth with open apices or immature root development.
* Presence of acute apical abscess with swelling or sinus tract.
* Patients with known allergy to sodium hypochlorite.
* Inability to achieve adequate isolation with rubber dam.
* Patients unable to attend follow-up or complete pain assessment forms.

Where it's running

• Atatürk University Faculty of Dentistry, Department of Endodontics
  Erzurum, Erzurum, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Kezban Meltem Çolak — Atatürk University, Faculty of Dentistry, Department of Endodontics
• Study coordinator: KEZBAN MELTEM ÇOLAK, Prof. Dr
• Email: meltem25@gmail.com
• Phone: +905325744027

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.