Using dexmedetomidine with bupivacaine for pain relief after heart surgery
Dexmedetomidine As an Adjuvant to Bupivacaine in Bilateral Pectoral Nerve Blocks for Postoperative Pain Control After Cardiac Surgeries: a Randomized Controlled Trial
This study is testing if adding dexmedetomidine to a standard pain relief method can help adults recovering from heart surgery feel less pain and recover faster.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 25 Years to 65 Years |
| Sex | All |
| Sponsor | Kasr El Aini Hospital Academic / other |
| Locations | 2 sites (Cairo and 1 other locations) |
| Trial ID | NCT06453681 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of dexmedetomidine as an additional pain relief option when combined with bupivacaine in bilateral pectoralis nerve blocks for patients undergoing cardiac surgeries. It involves 60 adult patients aged 25 to 65 who are scheduled for coronary artery bypass grafting or valve surgeries. Participants are randomly assigned to receive either the standard pectoralis nerve block or the block with dexmedetomidine. Pain levels will be assessed using a visual analog scale, and recovery metrics such as extubation time and inspiratory flow rate will be monitored.
Who should consider this trial
Good fit: Ideal candidates are adults aged 25 to 65 undergoing coronary artery bypass grafting or valve surgeries through midline sternotomy.
Not a fit: Patients with skin issues at the injection site, coagulopathy, or those requiring prolonged ventilation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance pain management and improve recovery times for patients after cardiac surgery.
How similar studies have performed: Previous studies have shown promising results with similar nerve block techniques, but the specific combination of dexmedetomidine and bupivacaine in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients between the age groups of 25 and 65 years undergoing either coronary artery bypass grafting (CABG) or valve surgeries through midline sternotomy under general anesthesia Exclusion Criteria: * Skin erosions, hematomas or infection at the injection site. * coagulopathy, ACT more than 150 seconds * History of hypersensitivity to bupivacaine or Dexametomedine. * The Patients who are unable to use the pain score. * patients who will need prolonged post-operative ventilation or inotropic support.
Where this trial is running
Cairo and 1 other locations
- Kasralainy school of medicine — Cairo, Egypt (Recruiting)
- Kasralaini Faculty of Medicine — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.