Using Dexamethasone to Improve Voice and Reduce Hypocalcemia After Thyroid Surgery
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
This study is testing if Dexamethasone can help improve voice quality and reduce low calcium levels in people having thyroid surgery for non-cancerous conditions.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tseung Kwan O Hospital, Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT05732883 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of Dexamethasone on voice outcomes and hypocalcemia in patients undergoing total thyroidectomy for benign conditions. It is a multi-specialty, double-blind, randomized, placebo-controlled trial conducted at two hospitals in Hong Kong. The study standardizes surgical techniques and peri-operative protocols to minimize confounding factors. Patients' vocal cord mobility and voice quality will be assessed before and after surgery, along with monitoring calcium levels to evaluate the impact of Dexamethasone.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and above undergoing total thyroidectomy for benign thyroid conditions.
Not a fit: Patients with malignant thyroid disease, previous thyroid surgeries, or pre-existing voice issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve voice recovery and reduce the incidence of hypocalcemia in patients undergoing thyroid surgery.
How similar studies have performed: Previous studies have indicated that Dexamethasone can effectively improve voice outcomes and reduce hypocalcemia in thyroidectomy patients, suggesting a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 or above * Patients undergoing total thyroidectomy for benign pathologies * MNG * Toxic nodular goitre * Graves' disease Exclusion Criteria: * Non-communicable patients * Patients contraindicated for steroid (DM, Hepatitis carrier, Tuberculosis, peptic ulcer disease) * Patients contraindicated for analgesics including Panadol, Celebrex, Tramadol or Levobupivacaine * Malignant thyroid disease * Patients with previous thyroid surgery, or neck surgery * Pre-existing hoarseness of voice of any cause or pre-existing vocal cord palsy * Pregnancy / Lactating female patients * Pre-existing renal disease / autoimmune disease on steroids * Patients who require steroid cover during operation e.g. hydrocortisone perioperatively
Where this trial is running
Hong Kong
- Department of Otorhinolaryngology, Head and Neck Surgery, United Christian Hospital and Tseung Kwan O Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Zenon YEUNG, MbChB — Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong
- Study coordinator: Cherrie Ng
- Email: cherrieng@ent.cuhk.edu.hk
- Phone: +85235051409
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.