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Clinical trial No longer in our active list Interventional

Using dexamethasone in adductor canal blocks for knee surgery pain management

Official title: Perineural Dexamethasone in the Adductor Canal Block for Postoperative Pain in Knee Arthroplasty Surgery

Run by University Tunis El Manar · NCT06079047 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if adding dexamethasone to a pain relief injection can help people having knee surgery feel less pain for longer without affecting their ability to move.

More Post Operative Pain trials

Quick facts

Study typeInterventional
SexAll
Enrollment66 (estimated)
SponsorUniversity Tunis El Manar
Academic / other
Locations1 site (Tunis, La Mannouba)
Trial IDNCT06079047 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients scheduled for unilateral total knee arthroplasty under spinal anesthesia with ASA class I, II, or III.

Probably not a fit

Patients with contraindications to regional anesthesia, those undergoing bilateral TKA, or those with poorly controlled diabetes may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of adding perineural dexamethasone to the adductor canal block for managing postoperative pain in patients undergoing total knee arthroplasty (TKA). Patients will be randomly assigned to receive either a combination of bupivacaine and dexamethasone or a control solution. The study aims to determine if dexamethasone can prolong the duration of sensory block, thereby improving pain management without compromising mobility. Pre-anesthesia evaluations will ensure patient safety and consent prior to the procedure.

Why it matters

Potential benefit: If successful, this approach could significantly enhance postoperative pain control for TKA patients, facilitating quicker recovery and rehabilitation.

How similar studies have gone: Previous studies have shown promising results with the use of dexamethasone in regional anesthesia, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Patients scheduled for unilateral TKA
* Surgery under spinal anesthesia
* ASA class I, II, and III patients

Exclusion Criteria:

* Patient refusal to participate in the study
* Contraindication to regional anesthesia
* Allergies to the products used
* Bilateral TKA
* Revision TKA
* TKA in the context of inflammatory or post-traumatic disease
* BMI \> 45
* Poorly controlled diabetic patients with HbA1c \> 8%
* Patients on corticosteroid therapy or who have received an intra-articular injection of corticosteroids

Where it's running

  • Kaabachi
    Tunis, La Mannouba, Tunisia     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Post Operative Pain 71University Tunis El Manar 3
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.