Using Deferiprone to Treat Heart Damage After a Heart Attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to evaluate the effectiveness of Deferiprone, a medication, in reducing free iron levels in the hemorrhagic zone of patients who have experienced an acute myocardial infarction. Participants will be randomly assigned to receive either Deferiprone tablets or a placebo. The study focuses on patients with anterior wall STEMI who undergo emergency coronary angiography with primary PCI. The goal is to determine if Deferiprone can improve outcomes in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. At least 18 years of age
2. Index Anterior wall STEMI
3. Emergency coronary angiogram with primary PCI

Exclusion Criteria

1. Prior history of MI / PCI / coronary artery bypass graft (CABG) within previous 1 year
2. Patients with previous history of left ventricular ejection fraction (LVEF) \< 40%
3. Use of investigational drugs or devices 30 days prior to randomization
4. Known allergy or contra-indication to gadolinium/contrast agents
5. eGFR \< 30 ml/kg/min
6. Any contraindication against cardiac MRI (such as metal implants)
7. Women who are pregnant or breastfeeding. Women of reproductive potential must have a negative pregnancy test prior to randomization
8. Body weight \> 140 kg (or 309 lbs.)
9. Absolute neutrophil count - ANC \< 1.5 k/cumm
10. History of Chronic Liver Disease
11. Elevated hepatic enzymes (BOTH ALT and AST) \> 2 times of upper normal limit
12. Patients with iron storage disease (hemochromatosis, thalassemia) or who are already treated with iron chelators
13. Any clinically significant abnormality identified prior to randomization that in the judgment of the Sponsor-Investigator or Delegate would preclude safe completion of the study or confound the anticipated benefit of deferiprone.
14. Life expectancy of less than 1 year due to non-cardiac pathology

Where it's running

• IU Methodist Hospital (IUHealth)
  Indianapolis, Indiana, United States Recruiting
• Minneapolis Heart Institute Foundation
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Keyur P Vora, MD FACP FACC — Medical Imaging Research Institute, Indiana University School of Medicine
• Study coordinator: Clinical Research Coordinator
• Email: csaha@iu.edu
• Phone: (317) 274-0985

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.