Using CT to Measure Heart Fibrosis in Atrial Fibrillation Patients Before Ablation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the link between myocardial fibrosis and outcomes in patients with Atrial Fibrillation (AF) undergoing catheter ablation. It utilizes Cardiac CT to measure left ventricular extracellular volume (ECV) as a potential indicator of fibrosis. The research aims to determine if higher ECV levels are associated with increased risks of AF recurrence, hospitalization, and poor recovery of cardiac function. By establishing this relationship, the study could influence treatment strategies for AF based on ECV measurements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients must be at least 21 years old at the time of enrollment.
* Patients must be able to give informed consent.
* Patients with symptomatic paroxysmal/persistent atrial fibrillation (AF).
* Eligible patients must be determined to be suitable candidates for ablation to treat AF by their cardiologist and/or electrophysiologists regardless of this protocol.
* Patients are scheduled to have a pre-procedure cardiac CT upon the discretion of their electrophysiologists

Exclusion Criteria:

* Known allergy to iodinated contrast media.
* Elevated serum creatinine (\> 1.5mg/dl) OR calculated creatinine clearance of \< 60 ml/min (using the Cockcroft-Gault formula).
* Patients with a positive urine or serum pregnancy test will be excluded from this study.
* Patients with heart transplantation.
* Patients with polymorphic ventricular tachycardia (VT) or presenting in electrical storm.
* Presence of any other history or condition that the investigator feels would be problematic.
* Patient with iodinated contrast administration for other reason 24 hours prior to investigational CT.
* Patients who have a heart pacemaker, metallic foreign body (metal sliver) in their eye, or who have an aneurysm clip in their brain, mechanical heart valves and prosthetics that contain metal.
* Patients with severe claustrophobia.

Where it's running

• Johns Hopkins Hospital
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Konstantinos Aronis, MD, PhD — Johns Hopkins School of Medicine
• Study coordinator: Konstantinos Aronis, MD PHD
• Email: karonis1@jhmi.edu
• Phone: 2017169226

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.