Using CT scans to diagnose and treat chest pain in patients with suspected coronary artery disease
Clinical Outcomes and Cost-effectiveness of a Diagnostic and Treatment Strategy of Upfront CTCA Plus Selective Non-invasive Functional Imaging Compared With Standard Care in Patients With Chest Pain and Suspected Coronary Artery Disease
This study tests if using CT scans to diagnose and treat chest pain can help people with suspected coronary artery disease feel better and avoid serious heart problems compared to standard care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 6444 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT05344612 on ClinicalTrials.gov |
What this trial studies
This clinical trial compares a new diagnostic and treatment strategy using computed tomography coronary angiography (CTCA) against standard of care (SOC) for patients experiencing chest pain and suspected coronary artery disease (CAD). The study aims to determine if the CTCA approach can reduce major adverse cardiac events and healthcare costs while improving patients' health status related to angina. It is a national multicenter prospective randomized controlled trial involving patients over 18 years old who meet specific eligibility criteria. The goal is to show that the CTCA strategy is at least as effective as the standard approach and potentially superior in clinical outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old experiencing chest pain with suspected coronary artery disease.
Not a fit: Patients with acute coronary syndrome, severe renal failure, or a history of obstructive coronary artery disease will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to better diagnosis and treatment of chest pain, reducing the risk of heart attacks and unnecessary procedures.
How similar studies have performed: Other studies have shown promise in using CTCA for diagnosing CAD, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years Exclusion Criteria: * Presentation with acute coronary syndrome * Acute coronary syndrome within last 3 months * History of obstructive coronary artery disease on imaging * History of PCI and/or CABG * Severe renal failure * Severe allergy to ionidated contrast medium * Known pregnancy * Patients with an estimated life expectancy of less than 1 year
Where this trial is running
Amsterdam, North Holland
- Amsterdam UMC — Amsterdam, North Holland, Netherlands (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.