Using CT radiomics to better characterize ovarian cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects pre-treatment portal-venous phase CT scans from adults with suspected or confirmed advanced epithelial ovarian cancer (FIGO stage ≥3B) who are planned for surgery and/or chemotherapy. Using radiomics, the team will extract quantitative imaging features from visible lesions (≥2 cm) and link those features to clinical data, histology, and treatment outcomes. No experimental interventions are given; researchers will analyze routine imaging and clinical records to build and test models that could predict prognosis or response. The work is led by Imperial College Healthcare NHS Trust with collaborators including the National Cancer Center, Korea.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written (signed and dated) informed consent
* Age 18 years or over
* Suspected or confirmed advanced epithelial ovarian cancer (FIGO stage 3B or more)
* Being considered for active anticancer treatment i.e. primary cytoreductive surgery followed by chemotherapy or neoadjuvant chemotherapy followed by interval cytoreductive surgery
* Evaluable baseline portal venous phase CT scan prior to surgical or medical treatment for ovarian cancer
* Disease visible on pre-treatment portal venous phase baseline CT scan (≥2cm)

Exclusion Criteria:

* Known contra-indication to CT with IV contrast (e.g. contrast allergy, renal failure, inability to lie flat);
* Unable to give informed consent;
* Known pregnancy;
* No visible disease \<2cm on portal venous phase baseline CT scan;
* Previous surgery for resection of an adnexal mass;
* Significant artefact on CT image for example from metal prostheses that precluded meaningful segmentation of visible disease
* Only fit for palliative care at initial presentation

Where it's running

• Imperial College NHS Healthcare Trust
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Christina Fotopoulou, MD, PhD
• Email: c.fotopoulou@imperial.ac.uk
• Phone: (+44) +44 (0)20 3313 3274

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.