Using CT Angiography to Diagnose Heart Disease After Cardiac Arrest
Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest
NA · CHU de Reims · NCT05961488
This study is testing if special heart scans can help doctors find out if patients who had a cardiac arrest without a heart attack actually have heart disease, so they can avoid unnecessary procedures.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | CHU de Reims (other) |
| Locations | 1 site (Reims) |
| Trial ID | NCT05961488 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of Coronary Calcium Score (CCS) and Coronary CT Angiogram (CCTA) in diagnosing coronary artery disease (CAD) in patients who have experienced an out-of-hospital cardiac arrest (OHCA) without ST-elevation myocardial infarction (STEMI). The goal is to determine if these non-invasive imaging techniques can accurately rule out CAD in the early days following OHCA, potentially avoiding unnecessary invasive procedures. The study will involve patients hospitalized in intensive care units after resuscitation from OHCA, with specific criteria to ensure appropriate candidate selection.
Who should consider this trial
Good fit: Ideal candidates are patients who have been resuscitated from an out-of-hospital cardiac arrest and do not show signs of ST-elevation myocardial infarction.
Not a fit: Patients who have in-hospital cardiac arrest, ST-elevation myocardial infarction, or other severe conditions such as cardiogenic shock will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to quicker and safer management of patients after cardiac arrest by reducing the need for invasive coronary procedures.
How similar studies have performed: While there is limited evidence on the timing of PCI in similar contexts, the use of non-invasive imaging techniques like CCTA has shown promise in other studies, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria : * Patients hospitalized in intensive care unit after a resuscitated out-of-hospital cardiac arrest * No obvious cause for sudden death on anamnestic information, CT brain and CT pulmonary angiogram. * Absence of ST elevation myocardial infarction Non-inclusion criteria : * In-hospital cardiac arrest * Refractory cardiac arrest * Indication of immediate coronary angiography * ST-elevation myocardial infarction or unknown left bundle branch block * Dynamic or presumably new contiguous ST/T-segment changes * Cardiogenic shock * Life-threatening arrhythmias * Coronary artery bypass graft * Pregnancy * Multiple organ failure syndrome * Know severe chronic kidney disease (GFR \<30mL/min/1,73m²) Exclusion criteria : * During the Coronary computerized tomographic angiogram : * Haemodynamic instability requiring high dose of vasopressors (\>1µg/kg/min of Norepinephrine) * Non sinusal cardiac rhythm * KDIGO 1 Acute kidney injury
Where this trial is running
Reims
- Damien JOLLY — Reims, France (RECRUITING)
Study contacts
- Study coordinator: Antoine GOURY
- Email: agoury@chu-reims.fr
- Phone: 03 10 73 68 85
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Out of Hospital Cardiac Arrest Without ST-segment Elevation, Cardiac arrest, Diagnostic accuracy, Coronary computarized tomography angiogram, Coronary Calcium Score, Non-ST Elevated Myocardial Infarction