Using CT Angiography to Diagnose Heart Disease After Cardiac Arrest
Official title: Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest
Run by CHU de Reims · NCT05961488 · Data updated 2026-11-12
This study is testing if special heart scans can help doctors find out if patients who had a cardiac arrest without a heart attack actually have heart disease, so they can avoid unnecessary procedures.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Status | Recruiting |
| Started | March 4, 2024 |
| Main results expected | June 2027 |
| Study ends | January 2028 |
| Registry record updated | March 6, 2024 |
| Trial ID | NCT05961488 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients who have been resuscitated from an out-of-hospital cardiac arrest and do not show signs of ST-elevation myocardial infarction.
✕Probably not a fit
Patients who have in-hospital cardiac arrest, ST-elevation myocardial infarction, or other severe conditions such as cardiogenic shock will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of Coronary Calcium Score (CCS) and Coronary CT Angiogram (CCTA) in diagnosing coronary artery disease (CAD) in patients who have experienced an out-of-hospital cardiac arrest (OHCA) without ST-elevation myocardial infarction (STEMI). The goal is to determine if these non-invasive imaging techniques can accurately rule out CAD in the early days following OHCA, potentially avoiding unnecessary invasive procedures. The study will involve patients hospitalized in intensive care units after resuscitation from OHCA, with specific criteria to ensure appropriate candidate selection.
Why it matters
Potential benefit: If successful, this approach could lead to quicker and safer management of patients after cardiac arrest by reducing the need for invasive coronary procedures.
How similar studies have gone: While there is limited evidence on the timing of PCI in similar contexts, the use of non-invasive imaging techniques like CCTA has shown promise in other studies, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria : * Patients hospitalized in intensive care unit after a resuscitated out-of-hospital cardiac arrest * No obvious cause for sudden death on anamnestic information, CT brain and CT pulmonary angiogram. * Absence of ST elevation myocardial infarction Non-inclusion criteria : * In-hospital cardiac arrest * Refractory cardiac arrest * Indication of immediate coronary angiography * ST-elevation myocardial infarction or unknown left bundle branch block * Dynamic or presumably new contiguous ST/T-segment changes * Cardiogenic shock * Life-threatening arrhythmias * Coronary artery bypass graft * Pregnancy * Multiple organ failure syndrome * Know severe chronic kidney disease (GFR \<30mL/min/1,73m²) Exclusion criteria : * During the Coronary computerized tomographic angiogram : * Haemodynamic instability requiring high dose of vasopressors (\>1µg/kg/min of Norepinephrine) * Non sinusal cardiac rhythm * KDIGO 1 Acute kidney injury
Where it's running
-
Damien JOLLY
Reims, France Recruiting
Study contacts
- Study coordinator: Antoine GOURY
- Email: agoury@chu-reims.fr
- Phone: 03 10 73 68 85
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.