Using corticosteroids to reduce pain in patients with irreversible pulpitis
Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
This study tests if using corticosteroid injections during root canal treatment can help reduce pain for people with severe toothaches caused by irreversible pulpitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Sponsor | Suez Canal University Academic / other |
| Locations | 1 site (Ismailia) |
| Trial ID | NCT06457828 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of local corticosteroids and maintaining apical patency in alleviating post-preparation pain in patients suffering from acute irreversible pulpitis in molar teeth. Participants will undergo root canal treatment and report their pain levels using a visual analogue scale, allowing researchers to compare outcomes between those receiving corticosteroid injections and those who do not, as well as between those with and without maintained apical patency. The study aims to provide insights into pain management strategies for this dental condition.
Who should consider this trial
Good fit: Ideal candidates are individuals with symptomatic acute irreversible pulpitis in molar teeth who meet specific health criteria.
Not a fit: Patients with conditions such as unrestorable teeth, marginal periodontal disease, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative pain for patients undergoing root canal treatment.
How similar studies have performed: While there is limited information on similar studies, the use of corticosteroids in dental procedures has shown promise in pain management, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic acute irreversible pulpitis in molar teeth. * Normal periapical condition including periapical radiography with minimal widening of periodontal ligament. * Normal probing depth. * No medical condition. * No contraindication for administration of corticosteroids and local anesthesia. Exclusion Criteria: * Facial or oral paresthesia. * Pregnancy \& breastfeeding. * Unrestorable tooth. * Marginal periodontal disease. * Presence of a crown on the tooth involved. * Over instrumentation during root canal treatment. * Long-term use of corticosteroids. * False-positive cases of sensibility test with necrosis discovered after gaining access to the tooth. * Cases requiring intrapulpal injection to promote anesthesia.
Where this trial is running
Ismailia
- Suez Canal University — Ismailia, Egypt (Recruiting)
Study contacts
- Study coordinator: Mustafa Sultan
- Email: sultan_mustafa@hotmail.com
- Phone: +201111506890
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.