Using CoQ10 to reduce inflammation and organ dysfunction in heart surgery patients
Protective Effect of Coenzyme Q10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiac and Aortic Surgery (PANDA V): a Randomized Controlled Trial
This study tests if giving CoQ10 to adults having heart surgery can help reduce inflammation and improve their recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Nanjing Medical University Academic / other |
| Locations | 4 sites (Beijing, Beijing Municipality and 3 other locations) |
| Trial ID | NCT04444349 on ClinicalTrials.gov |
What this trial studies
This study investigates the protective effects of Coenzyme Q10 (CoQ10) supplementation in adults undergoing cardiovascular surgery. It aims to determine whether CoQ10 can mitigate inflammatory responses and organ dysfunction associated with such procedures, independent of other lifestyle changes. Participants will receive CoQ10 alongside standard medical therapy to assess its efficacy in improving surgical outcomes. The study focuses on patients with decreased CoQ10 levels and mitochondrial dysfunction, which are common in cardiovascular disease.
Who should consider this trial
Good fit: Ideal candidates are adult men and women scheduled for cardiovascular surgery who consent to participate.
Not a fit: Patients who are pregnant or have significant metabolic syndrome traits may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery and reduced complications for patients undergoing cardiovascular surgery.
How similar studies have performed: Previous studies have shown promising results with CoQ10 supplementation in cardiovascular patients, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult men and women * Who receive cardiovascular surgery * Agree to participate in the surgery and sign the informed consent form Exclusion Criteria: * Pregnant or planning on getting pregnant during the study * Contain a minimum of 2 traits of metabolic syndrome * Refused to participate in the surgery and refused informed consent
Where this trial is running
Beijing, Beijing Municipality and 3 other locations
- Beijing Anzhen Hospital — Beijing, Beijing Municipality, China (Recruiting)
- The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China (Recruiting)
- The First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (Recruiting)
- West China Hospital of Sichuan University — Chengdu, Sichuan, China (Recruiting)
Study contacts
- Study coordinator: Hong Liu, MD
- Email: dr.hongliu@foxmail.com
- Phone: 8618801281613
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.