Using Colchicine to Prevent Atrial Fibrillation Recurrence After Heart Rhythm Restoration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of a 3-month low-dose Colchicine treatment in reducing the recurrence of Atrial Fibrillation (AF) following electrocardioversion (ECV). Atrial fibrillation is a prevalent cardiac arrhythmia that poses significant health risks, and current treatment options are insufficient as about 60% of patients experience a short-term recurrence after ECV. The researchers aim to explore the role of inflammation in AF and how targeting it with Colchicine may improve patient outcomes. The study will compare the effects of Colchicine against a placebo in eligible patients who have successfully converted to sinus rhythm after ECV.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years
* ECG-documented AF prior to ECV
* Successful ECV with conversion of AF to sinus rhythm with persistent sinus rhythm ≥30 minutes after ECV
* Ability to give written informed consent

Exclusion Criteria:

* AF persistence after cardioversion or early AF recurrence within 30 minutes after ECV
* Any other rhythm than AF before cardioversion
* Pulmonary vein isolation within 3 months prior to ECV or pulmonary vein isolation planned within 3 months after ECV
* Known intolerance or hypersensitivity to Colchicine
* Any other absolute indication for Colchicine intake
* Intake of a strong inhibitor of CYP3A4 or P-Glycoprotein (clarithromycin, erythromycin, telithromycin, cyclosporine, ketoconazole or itraconazole)
* Serious gastrointestinal disease (severe gastritis or diarrhea)
* Clinically overt hepatic disease
* Severe renal disease (eGFR\< 30ml/min/1.73m2)
* Clinically significant blood dyscrasia (e.g., myelodysplasia)
* Significant immunosuppression (e.g. due to transplantation or rheumatic disease)
* Pregnant or breastfeeding women, or women of child-bearing potential who do not use a highly effective form of birth control
* Life expectancy \<1 year

Where it's running

• Cantonal Hospital Baselland (KSBL)
  Bruderholz, Basel-Landschaft, Switzerland Recruiting
• University Hospital Basel
  Basel, Switzerland Recruiting
• University Hospital Bern
  Bern, Switzerland Recruiting
• Lausanne University Hospital
  Lausanne, Switzerland Recruiting
• Lucerne Cantonal Hospital
  Lucerne, Switzerland Recruiting
• Cantonal Hospital Olten
  Olten, Switzerland Recruiting

Study contacts

• Principal investigator: Philipp Krisai, PD Dr. med. — University Hospital, Basel, Switzerland
• Study coordinator: Philipp Krisai, PD Dr. med.
• Email: Philipp.krisai@usb.ch
• Phone: +41 61 265 25 25

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ablation of focal activation in atrial fibrillation

  This study is testing a new method to find specific electrical signals that may be causing ongoing atrial fibrillation in patients, to see if targeting these signals can improve their treatment.

  Recruiting Imperial College London · London · NCT06402617

• Evaluating new technologies for successful atrial fibrillation ablation

  This study is testing how well a common heart procedure called catheter ablation works for people with atrial fibrillation over a year to see if it helps keep their heart rhythm steady.

  Recruiting Azienda Ospedaliero, Universitaria Pisana · Pisa · NCT05617456

• Ablation of nerve endings in the right atrium for treating atrial fibrillation

  This study is testing a new procedure that targets nerve endings in the right side of the heart to help people with persistent atrial fibrillation who haven't found relief from standard treatments.

  Recruiting Imperial College London · London · NCT05539040

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities

  This study tests how comorbid conditions like sleep apnea and primary aldosteronism relate to left-atrial fibrosis and AF recurrence in patients undergoing ablation.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT07857044

• Dual Energy ablation with SmartTouch SF catheter in persistent atrial fibrillation

  This study tests a pulsed field and radiofrequency ablation system to treat persistent atrial fibrillation in adults who have not responded well to prior medications.

  Recruiting at 4 sites Biosense Webster, Inc. · Beijing and 3 other locations · NCT07845682

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.