Using Clopidogrel with Atorvastatin or Rosuvastatin for Minor Stroke or TIA Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of adding atorvastatin or rosuvastatin to the treatment regimen of patients experiencing a first-ever minor ischemic stroke or transient ischemic attack (TIA) who are already receiving clopidogrel and aspirin. The study will randomly assign 600 patients to receive either atorvastatin or rosuvastatin for three months, with clinical outcomes assessed using the NIH Stroke Scale and Modified Rankin Scale. The trial aims to evaluate the impact of these statins on recovery and potential adverse effects within the first 24 hours of treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* males and females aged 18-75
* first-ever moderate and small vessel Stroke
* Patients are not eligible for rt-PA treatment

Exclusion Criteria:

* The investigators excluded patients who had rapidly resolving symptoms before imaging results, and patients with a known history of persistent or recurrent CNS pathology (e.g., epilepsy, meningioma, multiple sclerosis, history of head trauma with a residual neurological deficit).
* the investigators excluded patients who had clinical seizures at the onset of their stroke, as well as those who had symptoms of any major organ failure, active malignancies, or an acute myocardial infarction within the previous six weeks, and those who were on warfarin, regular ticagrelor during the week before admission, or chemotherapy within the previous year.
* The investigators excluded patients with active peptic ulcers, GIT surgery, bleeding history within the last year, and those with a history of major surgery within the last three months.
* The investigators ruled out of our trial patients who had a known allergy to the study drugs and those with INR \> 1.4 or P.T. \>18 or blood glucose level \< 50 or \> 400 mg/DL or blood pressure \< 90/60 or \> 185/110 mmHg on admission or Platelets \< 100,000.
* The investigators excluded pregnant and lactating patients and those with stroke due to venous thrombosis and stroke following cardiac arrest or profuse hypotension ineligible for our trial.
* The investigators excluded patients who were regular users of drugs that affect clopidogrel metabolism, such as ketoconazole, dihydropyridine calcium channel blockers, and rifampin.

Where it's running

• Kafr Elsheikh University Hospital
  Kafr ash Shaykh, Egypt Recruiting

Study contacts

• Principal investigator: mohamed G. Zeinhom, MD — neurology department kafr el-sheikh university
• Study coordinator: mohamed G. Zeinhom, MD
• Email: mohamed_gomaa@med.kfs.edu.eg
• Phone: 2001009606828

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.