Using chlorhexidine and a probiotic lozenge to treat periodontitis
The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of Periodontitis
This study is testing if using chlorhexidine mouthwash along with probiotic lozenges can improve treatment results for people with severe gum disease who are already getting standard dental care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Cukurova University Academic / other |
| Locations | 1 site (Adana) |
| Trial ID | NCT05548361 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the additional effects of a two-week home regimen of chlorhexidine in patients with periodontitis who are also receiving scaling and root planing. Participants will be divided into groups receiving different combinations of chlorhexidine and probiotic lozenges, including active and placebo treatments. The goal is to determine if the combination therapy enhances the outcomes of standard periodontal treatment. The study will involve patients diagnosed with generalized stage III and IV periodontitis.
Who should consider this trial
Good fit: Ideal candidates are adults diagnosed with generalized stage III or IV periodontitis who are willing to participate and provide informed consent.
Not a fit: Patients with localized periodontitis, early-stage periodontitis, or those with systemic diseases affecting periodontal health may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve treatment outcomes for patients with periodontitis, leading to better oral health.
How similar studies have performed: While the combination of chlorhexidine and probiotics is a novel approach, similar studies have shown promise in enhancing periodontal treatment outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with generalized (\>30% of teeth affected) periodontitisstage III and IV periodontitis, grade B or C (C only with smoker modifier) = generalized chronic periodontitis including smokers * A minimum of three natural teeth in each quadrant, excluding third molars * Willing and able to give informed consent * Not more than 50% of the patients in each group will be smokers. * Smokers should smoke between 10 to 40 cigarettes a day Exclusion Criteria: * Patients with localized periodontitis or periodontitis stage I or II or grade A or grade C or grade C with diabetes modifier * Patients with orthodontic appliances (removable or fixed) * Pregnant or lactating woman * Patients with a history of systemic diseases that may correlate with periodontal health, such as diabetesrheumatic fever, liver or kidney disease, and neurological deficiencies * Patients taking medication which may affect the periodontium (bisphosphonates, phenytoin, cyclosporin, nifidepine, chronic use of non-steroidal anti-inflammatory drugs) * Patient who had taken systemic antibiotics up to 3 months prior to treatment or medical conditions requiring prophylactic antibiotic coverage * Participation in any other clinical study * Tobacco chewing or sniffing
Where this trial is running
Adana
- Cukurova university Faculty of Dentistry — Adana, Turkey (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.