Using carotid doppler peak velocity to predict fluid responsiveness during major abdominal surgery
Official title: Assessing Respiratory Variation of Carotid Doppler Peak Velocity (CDPV) for Non-invasive Prediction of Fluid Responsiveness During Abdominal Surgery: a Prospective Observational Trial
Run by Johannes Gutenberg University Mainz · NCT05185141 · Data updated 2026-11-12
This study is testing if measuring changes in blood flow in the carotid artery can help doctors decide how much fluid patients with septic shock need during major abdominal surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 84 (estimated) |
| Sponsor | Johannes Gutenberg University Mainz Academic / other |
| Locations | 1 site (Mainz, Rhineland-Palatinate) |
| Status | Recruiting |
| Started | January 11, 2022 |
| Main results expected | July 2026 |
| Study ends | July 2026 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT05185141 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-80 scheduled for major abdominal surgery.
✕Probably not a fit
Patients with severe comorbidities such as significant cardiac arrhythmias, heart failure, or severe lung disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the respiratory variation of carotid doppler peak velocity (∆CDPV) as a predictor of fluid responsiveness in patients undergoing major abdominal surgery. It will involve 84 patients scheduled for surgery, assessing how well ∆CDPV performs compared to established parameters like pulse pressure variation (∆PP) and corrected flow time (fTc). The study is particularly focused on patients with septic shock and aims to provide insights into hemodynamic monitoring during surgery. The findings could enhance the understanding of fluid management in surgical settings.
Why it matters
Potential benefit: If successful, this study could improve fluid management during major surgeries, leading to better patient outcomes.
How similar studies have gone: Previous studies have shown that ∆CDPV can predict fluid responsiveness effectively, but this approach is still being evaluated in broader surgical contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-80 years * written informed consent * scheduled major abdominal surgery Exclusion Criteria: * Age \<18 or \>80 years * pregnancy * SIRS or sepsis * any kind of cardiac arrhythmia * known valve disease * known heart failure * any kind of known carotid stenosis * carotid doppler peak velocity \>182 cm/s before baseline measurement (expected stenosis) * missing indication for invasive arterial blood pressure monitoring (IBP) not related to the study * peripheral artery disease (PAD) * BMI \> 35 kg/m2 * intraabdominal hypertension * ASA-PSC of 4 * severe lung disease (e.g. COPD grade 3, fibrosis) * esophageal disease of any kind * participation in another clinical study
Where it's running
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Department of Anesthesiology, Johannes-Gutenberg University Medical Center
Mainz, Rhineland-Palatinate, Germany Recruiting
Study contacts
- Study coordinator: Johannes M Wirkus, M.D.
- Email: johannes.wirkus@unimedizin-mainz.de
- Phone: +49 6131 17- 7175
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.