Using brain stimulation with treadmill training to improve walking in multiple sclerosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of transcranial direct current stimulation (tDCS) combined with gait training in patients with multiple sclerosis (MS). It employs a randomized, triple-blind, controlled design to compare the effects of active tDCS against a sham stimulation group, both undergoing the same gait training protocol. The study aims to enhance balance and walking ability, which are often compromised in MS patients, by measuring functional and clinical outcomes related to mobility, balance, and fatigue. The approach builds on previous evidence suggesting that tDCS may positively impact MS symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to understand and follow instructions.
* Diagnosis of Multiple Sclerosis according to McDonald criteria.
* Expanded Disability Status Scale (EDSS) between 1 and 6.
* Stable condition in the last three months.

Exclusion Criteria:

* Peripheral neurological injury of lower limbs.
* Metal objects in the head.
* Uncontrolled epilepsy.
* Diagnosis of psychiatric disorder.
* Fractures or fissures in the skull.
* Presence of any implanted electronic device (pacemaker, baclofen pump).
* Presence of ulcers in the harness attachment area.
* Osteoporotic fractures in the last 2 years.
* Height \> 190 cm.
* Weight \> 120 kg.

Where it's running

• Asociación de Esclerosis Múltiple de Toledo
  Toledo, Toledo, Spain Recruiting
• Universidad de Castilla La Mancha
  Toledo, Toledo, Spain Enrolling by invitation

Study contacts

• Study coordinator: Diego Serrano Muñoz, PhD
• Email: diego.serrano@uclm.es
• Phone: +34926051473

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Can moderate aerobic exercise combined with mild brain stimulation boost motor-cortex plasticity in older adults?

  We will see if a single session of moderate aerobic exercise, alone or followed by mild brain stimulation (tDCS), helps boost motor-cortex plasticity in healthy older adults compared with younger adults.

  Recruiting Universite du Littoral Cote d'Opale · Loos, Nord · NCT07438808

• Brain stimulation plus watching hand movements to improve hand recovery after chronic stroke

  This project will test whether combining gentle brain stimulation with watching and practicing hand movements helps adults 6–24 months after stroke improve hand function.

  Recruiting Universiti Malaysia Sabah · Kota Kinabalu, Sabah and 1 other locations · NCT07400939

• High-definition tDCS targeting the primary somatosensory cortex for adolescent bipolar depression

  This trial will try high-definition transcranial direct current stimulation (HD-tDCS) to reduce depressive symptoms in adolescents aged 12–18 with bipolar depression, compared with a sham procedure.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07246044

• Home-based brain stimulation versus duloxetine for fibromyalgia

  This trial will test whether home-based transcranial direct current stimulation (tDCS) works as well as duloxetine 60 mg for women with moderate-to-severe fibromyalgia when combined with exercise and pain education.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07203339

• Cerebello-spinal direct current stimulation to improve walking in chronic stroke

  Test whether cerebello-spinal direct current stimulation combined with daily treadmill training improves walking and mobility in people who had a stroke at least six months ago.

  Recruiting at 3 sites Phase 2 Universidade Federal de Pernambuco · João Pessoa, Paraíba and 2 other locations · NCT07073287

• Combining brain stimulation and therapy to reduce worrying

  This study is testing if combining brain stimulation with therapy can help people who often worry less than just therapy alone.

  Recruiting University Hospital, Ghent · Ghent, East-Flanders · NCT06369532

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.