Using brain stimulation to improve memory in older adults with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to enhance working memory in older adults and those with mild cognitive impairment (MCI) through closed-loop transcranial magnetic stimulation (TMS) targeted at the prefrontal cortex. The study will investigate how individualized brain networks can be used to optimize TMS parameters for better control of brain states. By measuring the effects of TMS on working memory performance and neural activity, the researchers hope to establish a reliable method for improving cognitive function in these populations. The approach addresses previous limitations in TMS efficacy by considering dynamic cognitive states and the influence of cerebrovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* English Speaking
* Willing to provide consent

Exclusion Criteria:

* History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders
* Current history of substance abuse or dependence (excluding nicotine)
* Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
* Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes.
* Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, Dementia, Hungtington chorea; Multiple Sclerosis.
* Current use of medications known to lower the seizure threshold and/or affect working memory

Where it's running

• Duke University Hospital
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Simon W Davis, PhD — Duke University
• Study coordinator: Simon W Davis, PhD
• Email: simon.davis@duke.edu
• Phone: 9196841243

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.