Using blood markers to tell apart bacterial and viral infections in emergency departments
Official title: Combination of Leukocyte Cell Surface Biomarkers Measured by Cytometry, to Differentiate Bacterial From Viral Infections in Emergency Department: a Multicentric Cohort for the Validation of Diagnostic Performances
Run by Assistance Publique - Hôpitaux de Paris · NCT06155266 · Data updated 2026-11-12
This study is testing if certain blood markers can help doctors quickly tell the difference between bacterial and viral infections in patients who come to the emergency room.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 3 sites (Paris and 2 other locations) |
| Status | Recruiting |
| Started | May 14, 2024 |
| Main results expected | August 14, 2025 |
| Study ends | August 14, 2025 |
| Registry record updated | January 13, 2025 |
| Trial ID | NCT06155266 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who present with a suspicion of infection in the emergency department.
✕Probably not a fit
Patients who are pregnant, lack social insurance, or are incarcerated will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to differentiate between bacterial and viral infections in patients attending emergency departments by analyzing specific cell surface biomarkers on leukocytes using flow cytometry. It will involve a multicentric cohort of 500 patients, with data collected from routine blood samples and clinical information recorded in an electronic case report form (eCRF). The study will evaluate the diagnostic performance of various combinations of these biomarkers against a reference standard established by an independent expert committee. The goal is to improve the accuracy of infection diagnosis in real-time, which is crucial for appropriate treatment decisions.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses of infections, potentially reducing unnecessary antibiotic use and improving patient outcomes.
How similar studies have gone: Previous studies have shown promising results in using cell surface biomarkers to differentiate between bacterial and viral infections, indicating that this approach has potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 year-old * Attending one of the participant ED from Monday to Friday between 8:30 am to 3:00 pm * With a suspicion of infection (defined by either a measured temperature above 38°C or any microbiology diagnostic test ordered during the routine care) * Having blood sampling during routine care * Informed and having expressed his/her non-opposition to participate Exclusion Criteria: * \- Pregnancy * No social insurance * Prisoners
Where it's running
-
Service des urgences, Pitié Salpêtrière
Paris, France Recruiting -
Service des urgences, Lariboisière
Paris, France Not yet recruiting -
Service des urgences, Saint-Antoine
Paris, France Not yet recruiting
Study contacts
- Study coordinator: laetitia Velly, MD
- Email: laetitia.velly@aphp.fr
- Phone: (33)7 82 28 94 91
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating biomarkers for melanoma immunotherapy response
This study is testing whether certain gut bacteria and blood markers can help predict how well immunotherapy works for people with advanced melanoma.
-
Respiratory infections in newborns and children up to five years
This project will follow newborns in Colombia and Panamá through age five to see how often respiratory infections happen, which germs cause them, and how those infections affect long-term lung health.
-
Stopping antibiotics early in older adults hospitalized with a viral lung infection
This trial will test whether stopping antibiotics early is safe and helpful for people 65 and older who are hospitalized with a confirmed viral lower respiratory infection.
-
Emergency PanorOmics Wide Association for Respiratory Infections
This study is trying to quickly identify different respiratory infections in adults visiting the emergency room to help develop better tests and treatments for these illnesses.
-
Older adults with viral lung infections: how common viruses show up in hospital patients
This observational study tests how often respiratory viruses are found in hospitalized people aged 60 and older using PCR tests.
-
Safety and PK of Ingavirin Forte vs Ingavirin in healthy adults under fasting and fed conditions
This early-phase study tests whether Ingavirin Forte (90 mg + 20 mg) is safe and how it behaves in the body compared with Ingavirin (90 mg) in healthy adults aged 18–45, under different meal conditions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.