Using blood extracellular vesicles to predict recovery after stroke and brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the predictive capacity of biomarkers associated with blood-derived extracellular vesicles (EVs) for anticipating recovery in patients after stroke and vascular severe brain injury (vSBI). By utilizing an optimized Surface Plasmon Resonance imaging (SPRi) biosensor, the study will assess various cell-derived families of EVs to understand their role in neuroinflammation, neuronal regeneration, and angiogenesis. The research will also investigate the correlation between EV biomarkers and rehabilitation outcomes, as well as their potential to identify patients at risk for healthcare-associated infections. Blood samples will be collected from eligible patients to analyze these biomarkers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Disability deriving from first ischemic or haemorrhagic stroke detected by MRI or CT scan
* Time from stroke onset or rehabilitation admission less than 1 month (for stroke) 3 months (for vSBI)
* Need of inward rehabilitation
* Signed informed consent by patient or legal representative

Exclusion Criteria:

* Subarachnoid haemorrhage
* Cerebral venous thrombosis
* Other previous neurological or psychiatric conditions
* Autoimmune diseases
* Previous severe and chronic infections conditions (e.g. tuberculosis, HIV/AIDS)
* Neoplasms or other malignant conditions
* Immunomodulatory medications (immunosuppressants).

Where it's running

• IRCCS "Don Gnocchi", Fondazione Don Gnocchi Onlus
  Florence, Italy Recruiting
• IRCCS "S. Maria Nascente", Fondazione Don Gnocchi Onlus
  Milan, Italy Recruiting
• "S. Maria ai Colli - Presidio Ausiliatrice", Fondazione Don Gnocchi Onlus
  Torino, Italy Recruiting

Study contacts

• Principal investigator: Alice Gualerzi, PhD — Fondazione Don Carlo Gnocchi, Laboratory of Nanomedicine and Clinical Biophotonics
• Study coordinator: Alice Gualerzi, PhD
• Email: agualerzi@dongnocchi.it
• Phone: +390240308533

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.