Using binaural sound to reduce anesthesia medication during surgery

The Effect of Intraoperative Binaural Sound on Remifentanil Dose Required for General Anesthesia Using Remimazolam: a Randomized, Placebo-controlled Trial

NA · Gangnam Severance Hospital · NCT06497283

This study is testing if using binaural sound during surgery can help reduce the amount of anesthesia needed for patients aged 20-60.

Quick facts

PhaseNA
Study typeInterventional
Enrollment72 (estimated)
Ages20 Years and up
SexAll
SponsorGangnam Severance Hospital (other)
Locations1 site (Seoul)
Trial IDNCT06497283 on ClinicalTrials.gov

What this trial studies

This study evaluates the impact of binaural sound on the maintenance of general anesthesia using remimazolam in patients undergoing surgery. The goal is to determine if binaural sound can effectively decrease the required dose of remifentanil, a common anesthetic agent. Patients aged 20-60 with specific health criteria will be included, while those with certain medical conditions or substance dependencies will be excluded. The intervention involves the application of binaural sound during the anesthesia process.

Who should consider this trial

Good fit: Ideal candidates are patients aged 20-60 scheduled for general anesthesia with a healthy physical status.

Not a fit: Patients with hearing disabilities or those with significant medical conditions such as cardiovascular disease will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to reduced medication requirements and improved safety during general anesthesia.

How similar studies have performed: While the use of binaural sound in anesthesia is a novel approach, similar studies exploring sound therapy in medical settings have shown promising results.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients scheduled for general anesthesia
2. Patients aged 20-60
3. Patients with American Society of Anesthesiologist physical status classification 1-2
4. Patients with ideal body weight 50-80 kg

Exclusion Criteria:

1. Patients with hearing disability
2. Patients using opioids or sedatives in 1 week
3. Patients who are dependent for alcoholics or drugs
4. Patients with hypersensitivities to remimazolam or remifentanil
5. Patients with arrhythmia, cardiovascular disease, heart failure, or hypovolemia
6. Patients with liver failure

Where this trial is running

Seoul

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: General Anesthesia, Prostate Cancer Stage, Uterine Myoma

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.