Using Bimatoprost eye drops to treat Graves' Orbitopathy
The Role of Bimatoprost in Graves' Periorbitopathy
EARLY_PHASE1 · Johns Hopkins University · NCT03708627
This study is testing if Bimatoprost eye drops can help reduce bulging eyes and other symptoms in people with Graves' disease.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 3 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University (other) |
| Locations | 1 site (Seattle, Washington) |
| Trial ID | NCT03708627 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the use of Bimatoprost, a topical eye drop typically prescribed for glaucoma, to induce fat atrophy around the eyes in patients suffering from Graves' disease. The study aims to assess the effectiveness of this treatment in reducing symptoms associated with Graves' Ophthalmopathy, particularly exophthalmos or proptosis. Participants will receive Bimatoprost ophthalmic solution and will be monitored for changes in their condition throughout the trial.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with Graves' Ophthalmopathy who exhibit exophthalmos or proptosis.
Not a fit: Patients who are currently pregnant, taking steroids, or have active Graves' disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with Graves' Orbitopathy, potentially improving their quality of life.
How similar studies have performed: While the use of Bimatoprost for this specific condition is novel, similar approaches using topical treatments for ocular conditions have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Graves' Ophthalmopathy with Exophthalmos/Proptosis - Exclusion Criteria: Active Graves Disease, Currently pregnant, Taking Steroids \-
Where this trial is running
Seattle, Washington
- University of Washington — Seattle, Washington, United States (RECRUITING)
Study contacts
- Principal investigator: Emily Li, MD — Johns Hopkins University
- Study coordinator: Emily Li, MD
- Email: eli20@jhmi.edu
- Phone: 410-955-1112
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Graves Ophthalmopathy