Using bicarbonate during in-hospital cardiac arrest
Bicarbonate for In-Hospital Cardiac Arrest - A Randomized, Double-Blind, Placebo-Controlled Trial
PHASE4 · Aarhus University Hospital · NCT05564130
This study tests if giving sodium bicarbonate during in-hospital cardiac arrest can help adults survive and have better brain function afterward.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 778 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Aarhus University Hospital (other) |
| Locations | 22 sites (Aabenraa and 21 other locations) |
| Trial ID | NCT05564130 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of sodium bicarbonate on adult patients experiencing in-hospital cardiac arrest. It is a multicenter, randomized, placebo-controlled, double-blind trial involving 778 patients across 22 sites in Denmark. Participants must have received at least one dose of adrenaline during CPR, and the study aims to determine if bicarbonate improves the chances of returning to spontaneous circulation and enhances survival rates at 30 days. The trial will also assess neurological outcomes for survivors.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have experienced an in-hospital cardiac arrest and received adrenaline during resuscitation efforts.
Not a fit: Patients with a do-not-resuscitate order, those on mechanical circulatory support, or those with clinical indications for bicarbonate administration may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could improve survival rates and neurological outcomes for patients experiencing cardiac arrest in hospitals.
How similar studies have performed: While the use of bicarbonate in cardiac arrest has been debated, this specific approach in a controlled setting is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. In-hospital cardiac arrest 2. Age ≥ 18 years 3. Received at least one dose of adrenaline during cardiopulmonary resuscitation (CPR) Exclusion Criteria: 1. Clearly documented "do-not-resuscitate" order prior to the cardiac arrest 2. Prior enrollment in the trial 3. Invasive mechanical circulatory support at the time of the cardiac arrest 4. Known or suspected pregnancy at the time of the cardiac arrest 5. Known objection by the patient to participate in the trial 6. Clinical indication for bicarbonate administration
Where this trial is running
Aabenraa and 21 other locations
- Hospital of Southern Jutland - Aabenraa — Aabenraa, Denmark (RECRUITING)
- Aalborg University Hospital — Aalborg, Denmark (RECRUITING)
- Aarhus University Hospital — Aarhus, Denmark (RECRUITING)
- Copenhagen University Hospital - Bispebjerg — Bispebjerg, Denmark (RECRUITING)
- Copenhagen University Hospital - Rigshospitalet — Copenhagen, Denmark (RECRUITING)
- Hospital of Southwest Jutland - Esbjerg — Esbjerg, Denmark (RECRUITING)
- Copenhagen University Hospital - Gentofte — Gentofte, Denmark (RECRUITING)
- Gødstrup Hospital — Gødstrup, Denmark (RECRUITING)
- Copenhagen University Hospital - Herlev — Herlev, Denmark (RECRUITING)
- North Denmark Region Hospital - Hjørring — Hjørring, Denmark (RECRUITING)
- Holbæk Hospital — Holbæk, Denmark (RECRUITING)
- Horsens Regional Hospital — Horsens, Denmark (RECRUITING)
- Hvidovre Hospital — Hvidovre, Denmark (RECRUITING)
- Kolding Hospital — Kolding, Denmark (RECRUITING)
- Zealand University Hospital - Køge — Køge, Denmark (RECRUITING)
- Nykøbing Falster Hospital — Nykøbing Falster, Denmark (NOT_YET_RECRUITING)
- Odense University Hospital — Odense, Denmark (RECRUITING)
- Randers Regional Hospital — Randers, Denmark (NOT_YET_RECRUITING)
- Zealand University Hospital - Roskilde — Roskilde, Denmark (RECRUITING)
- Slagelse Hospital — Slagelse, Denmark (RECRUITING)
- Odense University Hospital - Svendborg — Svendborg, Denmark (RECRUITING)
- Viborg Regional Hospital — Viborg, Denmark (RECRUITING)
Study contacts
- Principal investigator: Lars W Andersen — Aarhus University Hospital
- Study coordinator: Lars W Andersen
- Email: lwandersen@clin.au.dk
- Phone: +4551781511
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiac Arrest